发明申请
US20070004786A1 Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation
失效
氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
- 专利标题： Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation
- 专利标题（中）： 氨基-5-（5元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
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申请号： US11478122申请日： 2006-06-29
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公开(公告)号： US20070004786A1公开(公告)日： 2007-01-04
- 发明人: Michael Malamas , Ping Zhou , William Fobare , William Solvibile , Iwan Gunawan , James Erdei , Yinfa Yan , Patrick Andrae , Dominick Quagliato
- 申请人： Michael Malamas , Ping Zhou , William Fobare , William Solvibile , Iwan Gunawan , James Erdei , Yinfa Yan , Patrick Andrae , Dominick Quagliato
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; A61K31/422 ; A61K31/4196 ; C07D417/04 ; C07D413/04 ; C07D403/04
摘要：
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles