发明申请
US20070010539A1 SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES
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取代的8'-哌嗪（MI）十二烷基二 - [环己基] - 吡咯并[1,2-a]吡啶-6-酮衍生物
![SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES](/docs/US/2007-01-11/US20070010539A1/abs.jpg.600x600.jpg)
- 专利标题： SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES
- 专利标题（中）： 取代的8'-哌嗪（MI）十二烷基二 - [环己基] - 吡咯并[1,2-a]吡啶-6-酮衍生物
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申请号： US11423557申请日： 2006-06-12
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公开(公告)号： US20070010539A1公开(公告)日： 2007-01-11
- 发明人: Nathalie CHEREZE , Alistair LOCHEAD , Mourad SAADY , Franck SLOWINSKI , Philippe YAICHE
- 申请人： Nathalie CHEREZE , Alistair LOCHEAD , Mourad SAADY , Franck SLOWINSKI , Philippe YAICHE
- 申请人地址： FR Paris JP Osaka
- 专利权人： SANOFI-AVENTIS,MITSUBISHI PHARMA CORPORATION
- 当前专利权人： SANOFI-AVENTIS,MITSUBISHI PHARMA CORPORATION
- 当前专利权人地址： FR Paris JP Osaka
- 优先权： EP03293236.0 20031219
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/14
![SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKYLAMINE]-PYRIMIDO[1,2-a]PYRIMIDIN-6-ONE DERIVATIVES](/abs-image/US/2007/01/11/US20070010539A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.
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