发明申请
US20070010952A1 Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
审中-公开
包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质
- 专利标题： Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
- 专利标题（中）： 包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质
-
申请号： US11471290申请日： 2006-06-19
-
公开(公告)号： US20070010952A1公开(公告)日： 2007-01-11
- 发明人: David Armistead , Matthew Fitzgibbon , Mark Fleming , James Griffith , Eunice Kim , Joseph Kim , Michael Sintchak , John Thomson , Keith Wilson
- 申请人： David Armistead , Matthew Fitzgibbon , Mark Fleming , James Griffith , Eunice Kim , Joseph Kim , Michael Sintchak , John Thomson , Keith Wilson
- 主分类号： G06F19/00
- IPC分类号： G06F19/00 ; C07K14/705
摘要：
The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
信息查询
