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公开(公告)号：US12070645B2
公开(公告)日：2024-08-27
申请号：US17976780
申请日：2022-10-29
Applicant: David Diguardi , Mark Fleming
Inventor： David Diguardi , Mark Fleming
IPC: A63B21/06 , A63B21/072
CPC classification number: A63B21/0603 , A63B21/072
Abstract: An adjustable weight plate to be used with a standard or Olympic barbell handle, comprising a wide opening that is easy to fill with sand or other loose filler material, multiple inner compartments to separate out the sand and equalize the weight, and reinforcing dividers to strengthen the weight plate. The adjustable weight plate also comprises a metal collar to strengthen the inner radius of the weight plate, and an easy-fill funnel to fill the weight plate with sand.
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公开(公告)号：US10244895B2
公开(公告)日：2019-04-02
申请号：US15252780
申请日：2016-08-31
Applicant: Mark Fleming
Inventor： Mark Fleming
Abstract: An automated grill cleaning system for automatically cleaning a grill in a cooker includes a cooking unit that may be used to cook. The cooking unit has a housing and a grill is positioned in the housing. The housing has an outer wall. A cleaning unit is coupled to the cooking unit and the cleaning unit is positioned on the outer wall. The cleaning unit selectively engages the grill. The cleaning unit urges itself to travel along the grill to abrade debris from the grill.
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公开(公告)号：US20180056338A1
公开(公告)日：2018-03-01
申请号：US15252780
申请日：2016-08-31
Applicant: Mark Fleming
Inventor： Mark Fleming
CPC classification number: A47J37/0786 , A47J37/0704 , A47L13/34 , B08B1/002 , B08B1/005 , B08B1/008
Abstract: An automated grill cleaning system for automatically cleaning a grill in a cooker includes a cooking unit that may be used to cook. The cooking unit has a housing and a grill is positioned in the housing. The housing has an outer wall. A cleaning unit is coupled to the cooking unit and the cleaning unit is positioned on the outer wall. The cleaning unit selectively engages the grill. The cleaning unit urges itself to travel along the grill to abrade debris from the grill.
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公开(公告)号：US20100188286A1
公开(公告)日：2010-07-29
申请号：US12562099
申请日：2009-09-17
Applicant: Jacqueline Peta BICKERSTAFF , Esther Olulu ANYAEGBU , Peter Mark FLEMING , Gerald WHITWORTH
Inventor： Jacqueline Peta BICKERSTAFF , Esther Olulu ANYAEGBU , Peter Mark FLEMING , Gerald WHITWORTH
CPC classification number: G01S19/42 , G01S5/0205 , G01S19/258
Abstract: A time reference system for generating a time reference from signals produced by a global navigation satellite constellation has a satellite signal receiver to receive and down-convert code-modulated signals from a plurality of satellites and a correlator to track and decode the down-converted signals to provide signals containing partial pseudo-range measurements for respective satellites. A data processing arrangement receives assistance data from an external source and performs data-bit synchronisation in which bit edges of a low frequency data bit stream carried by the received satellite signals are identified, to perform a preliminary position-velocity-time solution to provide an approximate time reference, and to perform auto-correlation of pre-selected data sequences in the data stream to resolve time ambiguities thereby to compute a precise time reference signal in weak received signal conditions. The pre-selected data sequences may be the repeated data preamble in the GPS navigation message constituted by the data stream.
Abstract translation: 用于从由全球导航卫星星座产生的信号产生时间参考的时间参考系统具有卫星信号接收机，用于接收和降频来自多个卫星的码调制信号和相关器，以跟踪和解码下变频信号 以提供包含用于各个卫星的部分伪距测量的信号。 数据处理装置从外部源接收辅助数据，并执行数据位同步，其中识别由接收到的卫星信号携带的低频数据比特流的比特边，以执行初步位置 - 速度 - 时间解，以提供 近似时间参考，并且在数据流中执行预选数据序列的自相关以解决时间模糊度，从而在弱接收信号条件下计算精确的时间参考信号。 预先选择的数据序列可以是由数据流构成的GPS导航消息中的重复数据前导码。
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公开(公告)号：US07538861B2
公开(公告)日：2009-05-26
申请号：US12177003
申请日：2008-07-21
Applicant: David J. Zahniser , Matthew S. Zelinski , Thomas M. Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
Inventor： David J. Zahniser , Matthew S. Zelinski , Thomas M. Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
CPC classification number: G01N21/3151 , G01N1/30 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1472 , G01N2015/1488
Abstract: The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
Abstract translation: 本发明涉及细胞学材料的分析。 具体地说，本发明涉及染色剂的制造方法，染色细胞的细胞学或组织学分析方法，以将细胞的核部分与细胞质部分进行比较，以及用于照射细胞学样品的系统和方法。 分析可以自动或手动。
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Patent Agency Ranking
6.发明授权Method and apparatus for predicting and reporting a real estate value based on a weighted average of predicted values 有权基于预测值的加权平均值来预测和报告房地产价值的方法和装置公开(公告)号：US07305328B1
公开(公告)日：2007-12-04
申请号：US10975337
申请日：2004-10-29
Applicant: Mark Fleming , Chionglong Kuo
Inventor： Mark Fleming , Chionglong Kuo
IPC: G06F17/60
Abstract: A system and method of accurately predicting and reporting a value of a property based on a weighted average of values predicted by at least two prediction models. The system and method include the steps of accessing predicted values, determined by the prediction models, for the property; determining property-specific proportional prediction error distribution information for each predicted value determined by each prediction model; assigning a weight to the predicted value determined by each prediction model by using the property-specific proportional prediction error distribution information; and generating a property-specific weighted average value based on combination of the weight and the predicted value determined by each prediction model and reporting the property-specific weighted average value to minimize prediction error during prediction of the property value.
Abstract translation: 一种基于由至少两个预测模型预测的值的加权平均值来精确地预测和报告属性值的系统和方法。 该系统和方法包括访问由预测模型确定的用于属性的预测值的步骤; 确定由每个预测模型确定的每个预测值的特性比例预测误差分布信息; 通过使用所述特定的比例预测误差分布信息，将权重分配给由每个预测模型确定的预测值; 并且基于由每个预测模型确定的权重和预测值的组合来生成特性加权平均值，并且报告特性加权平均值，以在预测该属性值期间最小化预测误差。
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公开(公告)号：US20240139574A1
公开(公告)日：2024-05-02
申请号：US17976780
申请日：2022-10-29
Applicant: David Diguardi , Mark Fleming
Inventor： David Diguardi , Mark Fleming
IPC: A63B21/06 , A63B21/072
CPC classification number: A63B21/0603 , A63B21/072
Abstract: An adjustable weight plate to be used with a standard or Olympic barbell handle, comprising a wide opening that is easy to fill with sand or other loose filler material, multiple inner compartments to separate out the sand and equalize the weight, and reinforcing dividers to strengthen the weight plate. The adjustable weight plate also comprises a metal collar to strengthen the inner radius of the weight plate, and an easy-fill funnel to fill the weight plate with sand.
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8.发明申请Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof 有权Rho激酶I激酶结构域复合物的晶体结构及其结合位点公开(公告)号：US20090036654A1
公开(公告)日：2009-02-05
申请号：US11478194
申请日：2006-06-28
Applicant: Marc Jacobs , Koto Hayakawa , Mark Fleming , John Doran , Craig Marhefka
Inventor： Marc Jacobs , Koto Hayakawa , Mark Fleming , John Doran , Craig Marhefka
CPC classification number: C12N9/1205 , C07K2299/00
Abstract: The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.
Abstract translation: 本发明涉及人Rho-kinase I（ROCK I），ROCK I结合口袋，ROCK I样结合口袋。 更具体地说，本发明提供了一种计算机，其包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合ROCK I蛋白或ROCK I蛋白同源物的化合物（包括抑制性化合物）或其复合物的方法。 本发明还涉及包含与该结构域的抑制剂复合的ROCK I激酶结构域和ROCK I激酶结构域的可结晶组合物和晶体。 本发明还涉及鉴定ROCK I激酶结构域的抑制剂的方法。
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公开(公告)号：US09669253B2
公开(公告)日：2017-06-06
申请号：US14575940
申请日：2014-12-18
Applicant: Heather Fleming , Mark Fleming
Inventor： Heather Fleming , Mark Fleming
CPC classification number: A63B21/4037 , A63B2210/50
Abstract: A yoga mat comprising a folding hinge, said yoga mat designed to be folded and then rolled up while it is folded.
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公开(公告)号：US08184046B2
公开(公告)日：2012-05-22
申请号：US12562099
申请日：2009-09-17
Applicant: Jacqueline Peta Bickerstaff , Esther Olulu Anyaegbu , Peter Mark Fleming , Gerald Whitworth
Inventor： Jacqueline Peta Bickerstaff , Esther Olulu Anyaegbu , Peter Mark Fleming , Gerald Whitworth
IPC: G01S19/25
CPC classification number: G01S19/42 , G01S5/0205 , G01S19/258
Abstract: A time reference system for generating a time reference from signals produced by a global navigation satellite constellation has a satellite signal receiver to receive and down-convert code-modulated signals from a plurality of satellites and a correlator to track and decode the down-converted signals to provide signals containing partial pseudo-range measurements for respective satellites. A data processing arrangement receives assistance data from an external source and performs data-bit synchronization in which bit edges of a low frequency data bit stream carried by the received satellite signals are identified, to perform a preliminary position-velocity-time solution to provide an approximate time reference, and to perform auto-correlation of pre-selected data sequences in the data stream to resolve time ambiguities thereby to compute a precise time reference signal in weak received signal conditions. The pre-selected data sequences may be the repeated data preamble in the GPS navigation message constituted by the data stream.
Abstract translation: 用于从由全球导航卫星星座产生的信号产生时间参考的时间参考系统具有卫星信号接收机，用于接收和降频来自多个卫星的码调制信号和相关器，以跟踪和解码下变频信号 以提供包含用于各个卫星的部分伪距测量的信号。 数据处理装置从外部源接收辅助数据，并执行数据位同步，其中识别由接收到的卫星信号携带的低频数据比特流的比特边，以执行初步位置 - 速度 - 时间解，以提供 近似时间参考，并且在数据流中执行预选数据序列的自相关以解决时间模糊度，从而在弱接收信号条件下计算精确的时间参考信号。 预先选择的数据序列可以是由数据流构成的GPS导航消息中的重复数据前导码。
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