发明申请
US20070015732A1 Adenosine receptor antagonists and methods of making and using the same
审中-公开
腺苷受体拮抗剂及其制备和使用方法
- 专利标题： Adenosine receptor antagonists and methods of making and using the same
- 专利标题（中）： 腺苷受体拮抗剂及其制备和使用方法
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申请号： US11487764申请日： 2006-07-13
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公开(公告)号： US20070015732A1公开(公告)日： 2007-01-18
- 发明人: William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin
- 申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; A61K31/522 ; C07F9/6512 ; C07D473/02
摘要：
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
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