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1.发明申请公开(公告)号：US20070015732A1
公开(公告)日：2007-01-18
申请号：US11487764
申请日：2006-07-13
申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin
发明人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Chang , Ko Lin
IPC分类号： A61K31/675 , A61K31/522 , C07F9/6512 , C07D473/02
CPC分类号： C07D473/06 , C07D473/22 , C07F9/65616
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US20060252730A1
公开(公告)日：2006-11-09
申请号：US11484805
申请日：2006-07-10
申请人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Xi Chang , Ko Chung Lin
发明人： William Kiesman , Carol Ensinger , Russell Petter , James Dowling , Gnanasambandam Kumaravel , He Xi Chang , Ko Chung Lin
IPC分类号： A61K31/675 , A61K31/522 , C07F9/6512 , C07D473/04
CPC分类号： C07D473/06 , C07D473/22 , C07F9/65616
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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3.发明申请公开(公告)号：US20080004293A1
公开(公告)日：2008-01-03
申请号：US11829269
申请日：2007-07-27
IPC分类号： A61K31/52 , A61P11/00 , A61P11/06 , A61P25/00 , A61P25/16 , A61P25/24 , A61P3/10 , A61P9/00 , C07D473/00
CPC分类号： C07D473/02 , C07D473/04 , C07D473/06
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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4.发明申请公开(公告)号：US20050222179A1
公开(公告)日：2005-10-06
申请号：US11128550
申请日：2005-05-13
IPC分类号： A61K31/52 , A61K31/522 , A61P1/00 , A61P3/10 , A61P7/10 , A61P7/12 , A61P9/00 , A61P9/04 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D473/00 , C07D473/02 , C07D473/04 , C07D473/06 , C07D519/00
CPC分类号： C07D473/02 , C07D473/04 , C07D473/06
摘要： The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
摘要翻译： 本发明基于以下发现，即式I化合物是意想不到的高效和腺苷A 1受体的选择性抑制剂。 腺苷A 1拮抗剂可用于预防和/或治疗许多疾病，包括心脏和循环系统疾病，中枢神经系统的退行性疾病，呼吸系统疾病以及利尿剂治疗的许多疾病 适当。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US20070010520A1
公开(公告)日：2007-01-11
申请号：US10552305
申请日：2004-04-09
申请人： James Dowling , Gang Yao , Hexi Chang , Hairuo Peng , Jeffrey Vessels , Russell Petter , Gnanasambandam Kumaravel
发明人： James Dowling , Gang Yao , Hexi Chang , Hairuo Peng , Jeffrey Vessels , Russell Petter , Gnanasambandam Kumaravel
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D241/20 , C07D487/04
摘要： The invention is based on the discovery that compounds of formula (I) possess unexpectedly high affinity for the A2a adenosine receptor, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including Parkinson's disease. In one embodiment, the invention features a compound of formula I (See formula on paper copy)
摘要翻译： 本发明基于以下发现：式（I）化合物对A2a腺苷受体具有意想不到的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括帕金森病在内的许多疾病。 在一个实施方案中，本发明的特征在于式I的化合物（参见纸上的公式）
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公开(公告)号：US20120040951A1
公开(公告)日：2012-02-16
申请号：US13142603
申请日：2009-12-30
申请人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
发明人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
IPC分类号： A61K31/437 , A61K31/5377 , C07D417/14 , A61P35/00 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/12 , A61P19/08 , A61P1/16 , A61P7/00 , A61P3/10 , C12N9/99 , C07D471/04
CPC分类号： C07D261/08 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的式（I）化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US06735497B2
公开(公告)日：2004-05-11
申请号：US10105059
申请日：2002-03-22
申请人： Robert L. Wallace , Brian T. Hart , Richard D. Hart , Arthur A. Berube , Harold J. Liff , Liana Buciuman-Coman , James Dowling , Steve Piantedosi
发明人： Robert L. Wallace , Brian T. Hart , Richard D. Hart , Arthur A. Berube , Harold J. Liff , Liana Buciuman-Coman , James Dowling , Steve Piantedosi
IPC分类号： G06F1700
CPC分类号： G06F19/3462 , G06F19/00 , G06F19/326 , G06F19/3418 , G07F5/18 , G07F7/00 , G07F11/002 , G07F17/0092 , G16H10/60 , G16H40/63
摘要： The present invention relates to systems and methods for the remote dispensing of packaged and non-packaged medical products using networked communications systems. A preferred embodiment of the invention utilizes a network to provide for the secure delivery of confidential patient information and the sending of dispense instructions to a remote dispensing station. A preferred embodiment of the present invention relates to systems and methods of dispensing samples of drugs or other medical products. Another preferred embodiment of the invention provides a system and method for dispensing non-prescription medications.
摘要翻译： 本发明涉及使用联网通信系统远程分配包装和非包装医疗产品的系统和方法。 本发明的优选实施例利用网络来提供机密患者信息的安全传递和向远程分配站发送分配指令。 本发明的优选实施方案涉及分配药物或其它医疗产品样品的系统和方法。 本发明的另一优选实施方案提供了用于分配非处方药物的系统和方法。
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公开(公告)号：US20180022118A1
公开(公告)日：2018-01-25
申请号：US15547738
申请日：2015-04-17
发明人： Joan Solans , Charlie Yang , James Dowling
CPC分类号： B41J11/663 , B41J11/68 , B41J11/70
摘要： A method is provided. The method includes printing a target on a medium and defining at least one intended cutting line on the medium. The target includes at least one graphical element which defines at least one reference distance measure. The target is centered at the intended cutting line or has a defined distance to the intended cutting line.
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公开(公告)号：US20210404674A1
公开(公告)日：2021-12-30
申请号：US16910703
申请日：2020-06-24
申请人： James Dowling
发明人： James Dowling
摘要： A pressure equalization device for installation on or at an entry of an attic of a home or other building is described. The pressure equalization device can be an access panel of an attic access hatch. The access panel is a solid, generally flat panel of material such as wood or plastic. The access panel includes an aperture that passes therethrough. The aperture is covered with an air-permeable cover made from a material such as cloth or plastic mesh. The mesh is constructed to allow air to pass through the aperture between the attic and interior of the building for purposes of equalizing pressure between them. Pores of the mesh are sized so that insects, rodents, and other animals and dust and debris cannot pass through and into the interior of the building.
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公开(公告)号：US06564121B1
公开(公告)日：2003-05-13
申请号：US09454359
申请日：1999-12-03
申请人： Robert L. Wallace , Brian T. Hart , Richard D. Hart , Arthur A. Berube , Harold J. Liff , Liana Buciuman-Coman , James Dowling
发明人： Robert L. Wallace , Brian T. Hart , Richard D. Hart , Arthur A. Berube , Harold J. Liff , Liana Buciuman-Coman , James Dowling
IPC分类号： G06F1700
CPC分类号： G06F19/3462 , G06F19/00 , G06F19/326 , G06F19/3418 , G07F5/18 , G07F7/00 , G07F11/002 , G07F17/0092 , G16H10/60 , G16H40/63
摘要： The present invention relates to systems and methods for the remote dispensing of packaged and non-packaged medical products using networked communications systems. A preferred embodiment of the invention utilizes a network to provide for the secure delivery of confidential patient information and the sending of dispense instructions to a remote dispensing station. A preferred embodiment of the present invention relates to systems and methods of dispensing samples of drugs or other medical products. Another preferred embodiment of the invention provides a system and method for dispensing non-prescription medications.
摘要翻译： 本发明涉及使用联网通信系统远程分配包装和非包装医疗产品的系统和方法。 本发明的优选实施例利用网络来提供机密患者信息的安全传递和向远程分配站发送分配指令。 本发明的优选实施方案涉及分配药物或其它医疗产品样品的系统和方法。 本发明的另一优选实施方案提供了用于分配非处方药物的系统和方法。
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