Systems and methods for reversibly preventing the coupling of a non-volatile memory device to a host device such as a microcomputer are disclosed. Exemplary non-volatile memory devices include but are not limited to hard disk drives and flash memory devices. According to some embodiments, a locking mechanism reversibly prevents physical coupling. According to some embodiments, a mechanical locking mechanism is operative to prevent the coupling of the non-volatile memory to the host device when in a locked configuration, and upon engagement with a proper key the mechanical locking mechanism adopts an unlocked configuration to permit coupling of the non-volatile memory device to the host device. According to some embodiments, a locking mechanism prevents coupling of the non-volatile memory device to the host device without a presence of a proper electronic token.