发明申请
US20070020630A1 Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
审中-公开
识别靶向trna剪接内切核酸酶的化合物的方法和所述化合物作为抗增殖剂的用途
- 专利标题： Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
- 专利标题（中）： 识别靶向trna剪接内切核酸酶的化合物的方法和所述化合物作为抗增殖剂的用途
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申请号： US10551301申请日： 2004-03-26
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公开(公告)号： US20070020630A1公开(公告)日： 2007-01-25
- 发明人: Christopher Trotta
- 申请人： Christopher Trotta
- 国际申请： PCT/US04/09572 WO 20040326
- 主分类号： C40B30/06
- IPC分类号： C40B30/06 ; C40B40/08 ; A61K48/00
摘要：
The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer.
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