发明申请
US20070025995A1 Taxoid derivative covalently linked to tumor-specific antibody and a method for preparing the same
审中-公开
与肿瘤特异性抗体共价连接的紫杉烷衍生物及其制备方法
- 专利标题： Taxoid derivative covalently linked to tumor-specific antibody and a method for preparing the same
- 专利标题（中）： 与肿瘤特异性抗体共价连接的紫杉烷衍生物及其制备方法
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申请号： US11219686申请日： 2005-09-07
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公开(公告)号： US20070025995A1公开(公告)日： 2007-02-01
- 发明人: Hiroki Hamada , Katsuhiko Mikuni , Katsuyoshi Nakanishi , Tadakatsu Mandai
- 申请人： Hiroki Hamada , Katsuhiko Mikuni , Katsuyoshi Nakanishi , Tadakatsu Mandai
- 优先权： JP2005-222617 20050801
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/46
摘要：
To provide a taxoid derivative that has improved solubility in water and acts specifically with respect to tumors, thereby mitigating side effects. The present invention provides an anticancer agent comprises covalent bond compound of an antibody that reacts specifically with respect to cancer cells with a taxoid derivative and a method for preparing the anticancer agent according to claim 1, characterized by reacting, in the presence of reduction agent, an antibody that reacts specifically with respect to cancer cells with a reaction product obtained by allowing periodic acid or periodate to act on a taxoid derivative.
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