公开(公告)号：US10682330B2

公开(公告)日：2020-06-16

申请号：US14386855

申请日：2013-03-22

申请人： ENSUIKO SUGAR REFINING CO., LTD. ,  Hiroki Hamada ,  Ichiro Fujiwara ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

发明人： Hiroki Hamada ,  Ichiro Fujiwara ,  Masaharu Seno ,  Tomonari Kasai ,  Tsukasa Shigehiro ,  Masaharu Murakami ,  Katsuhiko Mikuni

IPC分类号： A61K31/337 ,  A61K47/26 ,  A61K9/127 ,  A61K31/7048 ,  C07K16/32 ,  A61K47/69 ,  A61K39/00

摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

公开(公告)号：US20160256566A2

公开(公告)日：2016-09-08

申请号：US14386855

申请日：2013-03-22

申请人： ENSUIKO SUGAR REFINING CO., LTD. ,  Hiroki HAMADA ,  Ichiro FUJIWARA ,  NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY

发明人： Hiroki HAMADA ,  Ichiro FUJIWARA ,  Masaharu SENO ,  Tomonari KASAI ,  Tsukasa SHIGEHIRO ,  Masaharu MURAKAMI ,  Katsuhiko MIKUNI

IPC分类号： A61K47/48 ,  A61K31/337

摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

公开(公告)号：US20100133989A1

公开(公告)日：2010-06-03

申请号：US12325883

申请日：2008-12-01

申请人： James Alexander Robert Stiles ,  Hiroki Hamada ,  Isao Yoshida

发明人： James Alexander Robert Stiles ,  Hiroki Hamada ,  Isao Yoshida

IPC分类号： H01J1/63 ,  B05D5/12

CPC分类号： C09K11/7734 ,  C09K11/7721 ,  H05B33/14

摘要： An extended area uniform light source providing uniform luminance is taught for displays and other applications where the light emission can be planar or have curvature. The uniform light source is achieved using a combination of a blue light-emitting electroluminescent layer and a highly stable inorganic photoluminescent colour conversion layer to tailor the colour spectrum of the emitted light. The invention thus encompasses the uniform light source, displays incorporating the uniform light sources as well of methods of making such light sources and displays.

摘要翻译： 针对显示器和发光可以是平面的或具有曲率的其他应用，教导了提供均匀亮度的扩展区域均匀光源。 使用蓝色发光电致发光层和高度稳定的无机光致发光颜色转换层的组合来实现均匀光源，以调整发射光的色谱。 因此，本发明包括均匀的光源，包含均匀光源的显示器以及制造这种光源和显示器的方法。

公开(公告)号：US20060267484A1

公开(公告)日：2006-11-30

申请号：US11432453

申请日：2006-05-11

申请人： James Stiles ,  John Moore ,  Vincent Pugliese ,  Hiroki Hamada ,  Isao Yoshida

发明人： James Stiles ,  John Moore ,  Vincent Pugliese ,  Hiroki Hamada ,  Isao Yoshida

IPC分类号： H05B33/14 ,  C09K11/56

CPC分类号： C09K11/7706 ,  C09K11/7703 ,  C09K11/7731 ,  C09K11/7734 ,  H05B33/10 ,  H05B33/12 ,  H05B33/14 ,  H05B33/22 ,  H05B33/26 ,  Y10S428/917

摘要： A thin film phosphor for an electroluminescent device, the phosphor being selected from the group consisting of thioaluminates, thiogallates and thioindates having at least one cation selected from elements of Groups IIA and IIB of the Periodic Table of Elements. The phosphor being activated by a rare earth metal and containing oxygen as a partial substitute for a portion of the sulphur in the crystal lattice of the thiogallate, thioindate or thioaluminate. The phosphor is a single phase homogeneous compound and provides improved luminance stability. An electroluminescent device comprising the thin film phosphor is also described and methods of making the phosphor of the invention.

公开(公告)号：US07112373B2

公开(公告)日：2006-09-26

申请号：US10417901

申请日：2003-04-17

申请人： James Alexander Robert Stiles ,  John Wesley Moore ,  Vincent Joseph Alfred Pugliese ,  Hiroki Hamada ,  Isao Yoshida

发明人： James Alexander Robert Stiles ,  John Wesley Moore ,  Vincent Joseph Alfred Pugliese ,  Hiroki Hamada ,  Isao Yoshida

IPC分类号： H05B33/14 ,  C09K11/62 ,  C09K11/64

CPC分类号： C09K11/7706 ,  C09K11/7703 ,  C09K11/7731 ,  C09K11/7734 ,  H05B33/10 ,  H05B33/12 ,  H05B33/14 ,  H05B33/22 ,  H05B33/26 ,  Y10S428/917

摘要： A thin film phosphor for an electroluminescent device, the phosphor being selected from the group consisting of thioaluminates, thiogallates and thioindates having at least one cation selected from elements of Groups IIA and IIB of the Periodic Table of Elements. The phosphor being activated by a rare earth metal and containing oxygen as a partial substitute for a portion of the sulphur in the crystal lattice of the thiogallate, thioindate or thioaluminate. The phosphor is a single phase homogeneous compound and provides improved luminance stability. An electroluminescent device comprising the thin film phosphor is also described and methods of making the phosphor of the invention.

公开(公告)号：US06630911B2

公开(公告)日：2003-10-07

申请号：US10024085

申请日：2001-12-17

申请人： Yoshikazu Kamei ,  Takanori Washiro ,  Hiroki Hamada ,  Takahiro Ueno ,  Masayuki Ishiwa

发明人： Yoshikazu Kamei ,  Takanori Washiro ,  Hiroki Hamada ,  Takahiro Ueno ,  Masayuki Ishiwa

IPC分类号： H01Q140

CPC分类号： H01Q1/40 ,  B29C33/005 ,  B29C45/0046 ,  B29C45/0055 ,  B29C45/14344 ,  B29C45/14639 ,  B29C45/14836 ,  B29C45/2669 ,  B29C45/4005 ,  B29C2045/0027 ,  B29L2031/3456 ,  H01Q1/242 ,  H01Q1/36

摘要： A compact antenna comprises a core which is a hard linear member having a predetermined shape corresponding to resonance characteristic, a conductor film which covers at least a portion of an outer surface of the core and which has higher electric conductivity than that of the core, and a substrate which closely surrounds and holds the outer surface of the core covered with the connection film. A film thickness of the conductor film is equal to a skin depth and thus, it is possible to inexpensively maintain reliability, and to prevent radiation efficiency from being lowered.

公开(公告)号：US06288412B1

公开(公告)日：2001-09-11

申请号：US08974746

申请日：1997-11-19

申请人： Hiroki Hamada ,  Kiichi Hirano ,  Nobuhiro Gouda ,  Hisashi Abe ,  Eiji Taguchi ,  Nobuhiko Oda ,  Yoshihiro Morimoto

发明人： Hiroki Hamada ,  Kiichi Hirano ,  Nobuhiro Gouda ,  Hisashi Abe ,  Eiji Taguchi ,  Nobuhiko Oda ,  Yoshihiro Morimoto

IPC分类号： H01L2900

CPC分类号： H01L21/02667 ,  G02F1/13454 ,  H01L21/02532 ,  H01L21/2022 ,  H01L27/12 ,  H01L29/66757

摘要： A method of manufacturing a polycrystalline silicon film having a particular field effect mobility is disclosed. A first polycrystalline silicon film is formed on a transparent insulation substrate. The surface of the silicon film is oxidized, and an amorphous silicon film is formed on the first polycrystalline silicon film and oxide layer. The amorphous silicon film is subjected to a solid phase growth process to be converted to a second polycrystalline silicon film. The field effect mobility of the second polycrystalline silicon film can be adjusted to a desired value by controlling the relative thicknesses of the first and second polycrystalline silicon films.

摘要翻译： 公开了制造具有特定场效应迁移率的多晶硅膜的方法。 在透明绝缘基板上形成第一多晶硅膜。 硅膜的表面被氧化，在第一多晶硅膜和氧化物层上形成非晶硅膜。 将非晶硅膜进行固相生长工艺以转变为第二多晶硅膜。 通过控制第一和第二多晶硅膜的相对厚度，可以将第二多晶硅膜的场效应迁移率调整到期望值。

公开(公告)号：US06232622B1

公开(公告)日：2001-05-15

申请号：US09406819

申请日：1999-09-28

申请人： Hiroki Hamada

发明人： Hiroki Hamada

IPC分类号： H01L2976

CPC分类号： H01L29/78696 ,  G02F1/13454 ,  H01L29/66757 ,  H01L29/66765 ,  H01L29/78621 ,  H01L29/78675

摘要： A polycrystalline silicon TFT of a top-gate type having a polycrystalline silicon film functioning as an active layer on a transparent insulating substrate. A gate electrode is provided on a channel region of the polycrystalline silicon film via a gate insulating film. On both sides of the channel region, source-drain regions of LDD structure consisting of low impurity concentration regions and high impurity concentration regions are provided. In the channel region of the polycrystalline silicon film, multiple monocrystal regions connecting source-drain regions are provided perpendicular to the transparent insulating substrate. Though electrons cannot smoothly pass through the channel region of the polycrystalline silicon film because of crystal grain boundaries and crystal defects therein, electric field effect mobility can be heightened by providing monocrystal regions, since electrons can smoothly pass through the monocrystal regions.

摘要翻译： 一种顶栅型的多晶硅TFT，其具有在透明绝缘基板上用作有源层的多晶硅膜。 栅电极通过栅极绝缘膜设置在多晶硅膜的沟道区上。 在沟道区域的两侧，设置由低杂质浓度区域和高杂质浓度区域构成的LDD结构的源极 - 漏极区域。 在多晶硅膜的沟道区域中，连接源极 - 漏极区的多个单晶区垂直于透明绝缘基片设置。 尽管电子由于其晶界和晶体缺陷而不能平滑地通过多晶硅膜的沟道区，但通过提供单晶区，可以提高电场效应迁移率，因为电子可以平滑地通过单晶区。

公开(公告)号：US5684169A

公开(公告)日：1997-11-04

申请号：US470018

申请日：1995-06-06

申请人： Hiroki Hamada ,  Kyoko Saito ,  Katsuhiko Mikuni ,  Nobuhiro Kuwahara ,  Hideki Takahashi

发明人： Hiroki Hamada ,  Kyoko Saito ,  Katsuhiko Mikuni ,  Nobuhiro Kuwahara ,  Hideki Takahashi

IPC分类号： A61K31/335 ,  A61K47/48 ,  C07D305/14

CPC分类号： B82Y5/00 ,  A61K31/335 ,  A61K47/48969

摘要： There is provided an unbranched cyclodextrin or a branched cyclodextrin inclusion complex of taxol. The complex is produced by adding an unbranched cyclodextrin of a branched cyclodextrin to taxol at a molar ratio of 1-20 times with respect to taxol. A method is provided for the improvement of the solubility of taxol in water by adding an unbranched cyclodextrin or a branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to taxol. The solubility of taxol in water is improved by the present invention. A cyclodextrin inclusion complex of taxol according to the present invention serves to make taxol more easily absorbed when administered to a cancer patient, which is beneficial to cancer patients and the physiological effects of taxol may therefore be more effectively induced.

摘要翻译： 提供紫杉醇的无支链环糊精或支链环糊精包合物。 通过将支链环糊精的无支链环糊精与紫杉醇以相对于紫杉醇为1-20倍的摩尔比添加到紫杉醇中而制备。 提供了一种通过以相对于紫杉醇为1-20倍的摩尔比添加无支链环糊精或支链环糊精来提高紫杉醇在水中的溶解度的方法。 本发明提高了紫杉醇在水中的溶解度。 根据本发明的紫杉醇的环糊精包合物用于在给予癌症患者时更容易地吸收紫杉醇，这有利于癌症患者，因此可以更有效地诱导紫杉醇的生理作用。

公开(公告)号：US5264389A

公开(公告)日：1993-11-23

申请号：US896386

申请日：1992-06-10

申请人： Hiroki Hamada ,  Shoji Honda ,  Masayuki Shono ,  Takao Yamaguchi

发明人： Hiroki Hamada ,  Shoji Honda ,  Masayuki Shono ,  Takao Yamaguchi

IPC分类号： H01S5/22 ,  H01S5/32 ,  H01S5/323 ,  H01S5/343 ,  H01L21/20

CPC分类号： B82Y20/00 ,  H01S5/32 ,  H01S5/32325 ,  H01S2304/04 ,  H01S5/22 ,  H01S5/3202 ,  H01S5/34326 ,  Y10S148/064 ,  Y10S148/11 ,  Y10S438/973

摘要： A semiconductor laser device of an AlGaInP system includes a GaAs substrate and a surface of the substrate is inclined by 5.degree. or more from a {100} plane in a direction.

摘要翻译： AlGaInP系统的半导体激光器件包括GaAs衬底，并且衬底的表面在<011>方向上从{100}面倾斜5°或更多。