A color correction method includes for each of a plurality of color separations of a digital image, establishing a tone reproduction curve in the form of a vector. The vector is a function of a plurality of basis vectors. The basis vectors account for colorant interactions between a primary colorant with which the color separation is to be rendered and at least one secondary colorant with which at least a second of the plurality of color separations is to be rendered. The vector includes modified input values corresponding to input values for the color separation which vary, depending on the input values of at least the second color separation. For a pixel of interest in the digital image, a modified input value for the color separation which corresponds to the input value of the given color separation is identified from the vector.