A dynamic bus inversion (DBI) method and system are described. In various embodiments, a transmitter transmits data over a multi-bit high-speed bus to a receiver. In an embodiment, the transmitter determines whether to invert the bus based on the number of data bits that will be transitioning to a new value. If it is determined that the bus is to be inverted, the transmitter encodes a DBI signal on a shared line of the bus. In an embodiment, the shared line is used for different purposes at different times, obviating the need for a dedicated line or pin for the encoded DBI signal. The receiver receives and decodes the DBI signal and, in response, appropriately decodes the received data.