An internal combustion engine incorporating rest cylinders is provided which does not need a high response performance when operating a throttle valve and which can eliminate engine output variations as the number of operable cylinders changes. In the internal combustion engine, some of a plurality of cylinders is configured to rest during normal operation of the engine. The cylinders are divided into a plurality of cylinder groups, and each of the cylinders is provided with an independent throttle valve. An ECU for increasing the number of operative cylinder groups according to at least the throttle handgrip opening is provided. Also provided are motors for bringing the throttle valves in the cylinder in the rest state into a fully closed state on the basis of each cylinder group, a throttle valve position sensor, and the like.