In a single-carrier frequency division multiple access (SC-FDMA) system that utilizes interleaved FDMA (IFDMA) or localized FDMA (LFDMA), a transmitter generates modulation symbols for different types of data (e.g., traffic data, signaling, and pilot) and performs code division multiplexing (CDM) on at least one data type. For example, the transmitter may apply CDM on signaling and/or pilot sent on frequency subbands and symbol periods that are also used by at least one other transmitter. To apply CDM to a given data type (e.g., signaling), the transmitter performs spreading on the modulation symbols for that data type with an assigned spreading code. CDM may be applied across symbols, samples, samples and symbols, frequency subbands, and so on. The transmitter may perform scrambling after the spreading. The transmitter generates SC-FDMA symbols of the same or different symbol durations for traffic data, signaling, and pilot and transmits the SC-FDMA symbols.