发明申请
US20070043085A1 Process for the preparation of amorphous form of neutral esomeprazole
审中-公开
制备中性埃索美拉唑无定形形式的方法
- 专利标题： Process for the preparation of amorphous form of neutral esomeprazole
- 专利标题（中）： 制备中性埃索美拉唑无定形形式的方法
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申请号： US11507284申请日： 2006-08-21
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公开(公告)号： US20070043085A1公开(公告)日： 2007-02-22
- 发明人: Bobba Kumar , Pravin Kulkarni , Anil Suryawanshi , Changdev Raut , Nitin Pradhan
- 申请人： Bobba Kumar , Pravin Kulkarni , Anil Suryawanshi , Changdev Raut , Nitin Pradhan
- 申请人地址： IN Mumbai
- 专利权人： Glenmark Pharmaceuticals Limited
- 当前专利权人： Glenmark Pharmaceuticals Limited
- 当前专利权人地址： IN Mumbai
- 优先权： IN979/MUM/2005 20050819
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D403/02
摘要：
A process for preparing neutral esomeprazole in an amorphous form is provided comprising (a) providing an aqueous solution comprising a salt of esomeprazole; (b) neutralizing the solution with a neutralization agent to provide a neutralized solution; (c) contacting the neutralized solution with an extracting solvent; and (d) recovering the neutral esomeprazole in an amorphous form.
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