发明申请
- 专利标题： Method of treating dopaminergic and GABA-nergic disorders
- 专利标题（中）： 治疗多巴胺能和GABA无能障碍的方法
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申请号： US11586768申请日： 2006-10-25
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公开(公告)号： US20070048286A1公开(公告)日： 2007-03-01
- 发明人: Ningning Miao , Monica Wang , Nagesh Mahanthappa , Ping Jin , Kevin Pang
- 申请人： Ningning Miao , Monica Wang , Nagesh Mahanthappa , Ping Jin , Kevin Pang
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/04 ; C12P21/06 ; C07K14/47 ; A61K31/47 ; C07K16/18 ; A61K48/00
摘要：
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.
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