发明申请
- 专利标题： Rational Chemical Modification of Adiponectin Variants
- 专利标题（中）： 脂联素变体的合理化学修饰
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申请号： US11421062申请日： 2006-05-30
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公开(公告)号： US20070054359A1公开(公告)日： 2007-03-08
- 发明人: Jonathan Zalevsky , Duc-Hanh Nguyen , Gregory Moore , Sergei Ezhevsky , John Desjarlais , Arthur Chirino , Darian Cash , Matthew Bernett
- 申请人： Jonathan Zalevsky , Duc-Hanh Nguyen , Gregory Moore , Sergei Ezhevsky , John Desjarlais , Arthur Chirino , Darian Cash , Matthew Bernett
- 主分类号： C07K14/475
- IPC分类号： C07K14/475 ; C07K14/52 ; C12P21/06
摘要：
An adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin, wherein the adiponectin variant has at least one covalently attached non-peptide moiety at at least one position selected from the group consisting of: A108, Y109, S146, D179, E220, R221, and L224, relative to human adiponectin