发明申请
- 专利标题: Template-fixed peptidomimetics with antimicrobial activity
- 专利标题(中): 具有抗菌活性的模板固定肽模拟物
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申请号: US10530335申请日: 2002-10-02
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公开(公告)号: US20070054840A1公开(公告)日: 2007-03-08
- 发明人: Jan Vrijbloed , Daniel Obrecht , John Robinson , Sergio Locurio , Frank Gombert , Christian Ludin , Alexander Lederer , Shivaprasad Shankaramma
- 申请人: Jan Vrijbloed , Daniel Obrecht , John Robinson , Sergio Locurio , Frank Gombert , Christian Ludin , Alexander Lederer , Shivaprasad Shankaramma
- 优先权: JP2002-350043 20021202; JP2003-358541 20031017
- 国际申请: PCT/EP02/11048 WO 20021002
- 主分类号: A61K38/12
- IPC分类号: A61K38/12 ; C07K7/60
摘要:
Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly or Pro, or of certain types, at least one of these residues being of the type of N-substituted glycines, which types, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit the growth of or to kill microorganisms. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
公开/授权文献
- US07855179B2 Template-fixed peptidomimetics with antimicrobial activity 公开/授权日:2010-12-21