利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

132 条记录 (耗时 0.041 秒)

    Template-fixed peptidomimetics with antimicrobial activity
    1.
    发明申请
    Template-fixed peptidomimetics with antimicrobial activity 有权
    具有抗菌活性的模板固定肽模拟物

    公开(公告)号：US20070054840A1

    公开(公告)日：2007-03-08

    申请号：US10530335

    申请日：2002-10-02

    申请人： Jan Vrijbloed ,  Daniel Obrecht ,  John Robinson ,  Sergio Locurio ,  Frank Gombert ,  Christian Ludin ,  Alexander Lederer ,  Shivaprasad Shankaramma

    发明人： Jan Vrijbloed ,  Daniel Obrecht ,  John Robinson ,  Sergio Locurio ,  Frank Gombert ,  Christian Ludin ,  Alexander Lederer ,  Shivaprasad Shankaramma

    IPC分类号： A61K38/12 ,  C07K7/60

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/001

    摘要： Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly or Pro, or of certain types, at least one of these residues being of the type of N-substituted glycines, which types, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit the growth of or to kill microorganisms. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

    摘要翻译： 通式（I）的模板固定的β-发夹肽模拟物，其中Z是12个α-氨基酸残基的模板固定链，其取决于其在链中的位置（从N-末端氨基酸开始计数） 是Gly或Pro，或某些类型，这些残基中的至少一种是N-取代的甘氨酸类型，其类型作为上述式中的其余符号在说明书和权利要求书中定义，以及其盐 具有抑制微生物生长或杀死微生物的性质。 它们可以用作食品，化妆品，药​​物或其他含营养材料的消毒剂，或用作治疗或预防感染的药物。 这些β-发夹肽模拟物可以通过基于混合固相和溶液相合成策略的方法制备。

    Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
    2.
    发明申请
    Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity 有权
    具有cxcr4拮抗活性的模板固定β-发夹肽模拟物

    公开(公告)号：US20070078079A1

    公开(公告)日：2007-04-05

    申请号：US10555088

    申请日：2004-04-29

    申请人： Jurg Zumbrunn ,  Steven Demarco ,  Sergio Lociuro ,  Jan Vrijbloed ,  Frank Gombert ,  Reshmi Mukherjee ,  Kerstin Moehle ,  Daniel Obrecht ,  John Robinson ,  Heiko Henze ,  Barbara Romagnoli ,  Christian Ludin

    发明人： Jurg Zumbrunn ,  Steven Demarco ,  Sergio Lociuro ,  Jan Vrijbloed ,  Frank Gombert ,  Reshmi Mukherjee ,  Kerstin Moehle ,  Daniel Obrecht ,  John Robinson ,  Heiko Henze ,  Barbara Romagnoli ,  Christian Ludin

    IPC分类号： A61K38/12 ,  C07K5/12

    CPC分类号： C07K7/64 ,  A61K38/00 ,  C07K1/047 ,  C07K7/08

    摘要： Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid and solution phase synthetic strategy.

    摘要翻译： 通式（I）的模板固定的β-发夹肽模拟物，其中Z是12,14或18个α-氨基酸残基的模板固定链，其取决于其在链中的位置（从N-末端开始计数 氨基酸）是Gly，NMeGly，Pro或Pip，或某些类型，其作为上述式中的其余符号在说明书和权利要求书及其权利要求书中定义，及其盐具有CXCR4拮抗特性，可用于 预防健康人中的艾滋病毒感染或减缓和停止感染患者的病毒进展; 或由CXCR4受体活性介导或产生癌症; 或其中免疫性疾病介导或由CXCR4受体活性产生; 或用于治疗免疫抑制; 或在外周血干细胞的分离采集期间。 这些β-发夹肽模拟物可以通过基于混合固相和溶液相合成策略的方法制备。

    Template-fixed peptidomimetics with antibacterial activity
    3.
    发明申请
    Template-fixed peptidomimetics with antibacterial activity 有权
    具有抗菌活性的模板固定肽模拟物

    公开(公告)号：US20050239693A1

    公开(公告)日：2005-10-27

    申请号：US11062021

    申请日：2005-02-18

    申请人： Jan Vrijbloed ,  Daniel Obrecht ,  John Robinson ,  Odile Sellier ,  Marc Kessler

    发明人： Jan Vrijbloed ,  Daniel Obrecht ,  John Robinson ,  Odile Sellier ,  Marc Kessler

    IPC分类号： A61K38/00 ,  A61P31/04 ,  C07K1/04 ,  C07K5/078 ,  C07K7/64 ,  A61K38/12 ,  C07K5/12

    CPC分类号： C07K5/06165 ,  A61K38/00 ,  C07K1/047 ,  C07K7/64 ,  Y02A50/473

    摘要： Template-fixed β-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa and Acinetobacter. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

    摘要翻译： 模板固定的β-发夹肽模拟物，其通式如下：其中Z是12个α-氨基酸残基的模板固定链，其取决于其在链中的位置（从N-末端氨基酸开始计数）为Gly，或 Pro或某些类型，其作为上述式中的其余符号在说明书和权利要求书及其盐中定义，具有选择性抑制绿脓假单胞菌和不动杆菌等微生物生长或杀死微生物的性质。 它们可以用作食品，化妆品，药​​物或其他含营养材料的消毒剂，或用作治疗或预防感染的药物。 这些β-发夹肽模拟物可以通过基于混合固相和溶液相合成策略的方法制备。

    Synthesis of template-fixed beta-hairpin loop mimetics
    4.
    发明申请
    Synthesis of template-fixed beta-hairpin loop mimetics 有权
    模板固定β-发夹环模拟物的合成

    公开(公告)号：US20050181454A1

    公开(公告)日：2005-08-18

    申请号：US11029331

    申请日：2005-01-05

    申请人： John Robinson ,  Daniel Obrecht

    发明人： John Robinson ,  Daniel Obrecht

    IPC分类号： C07K5/10 ,  C07H21/04 ,  C07K1/04 ,  C07K7/02 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/00 ,  G01N33/53

    CPC分类号： C07K7/06 ,  C07K1/04 ,  C07K7/02 ,  C07K7/08 ,  C07K7/64

    摘要： Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed β-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed β-hairpin loop mimetics themselves are also novel compounds. The template-fixed β-hairpin loop mimetics and their enantiomers can mimic flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.

    摘要翻译： 模板固定的β-发夹环模拟物，其包含对应于结构（a），（b），（c），（d），（e），（f），（g），（h）和 4至20个α-氨基酸残基的模板固定链，如果它们的α-C原子是不对称的，则具有L-构型可以通过基于混合固相和溶液相合成策略的新方法制备。 如果需要，可以修饰该方法以得到这些模板固定的β-发夹环模拟物的对映异构体。 这些对映体是新化合物，许多所述模板固定的β-发夹环模拟物本身也是新的化合物。 模板固定的β-发夹环模拟物及其对映体可以模拟蛋白质的平坦表面，因此可用于探测大的表面蛋白质 - 蛋白质相互作用。 因此，它们可以作为难以发现小分子量铅化合物的蛋白质靶标的主要发现工具。

    Template-fixed peptidomimetics as medicaments against hiv and cancer
    5.
    发明申请
    Template-fixed peptidomimetics as medicaments against hiv and cancer 有权
    模板固定肽模拟物作为抗HIV和癌症的药物

    公开(公告)号：US20060234923A1

    公开(公告)日：2006-10-19

    申请号：US10550778

    申请日：2003-05-02

    申请人： Jurg Zumbrunn ,  Steven Demarco ,  Sergio Lociuro ,  Daniel Obrecht ,  Barbara Romagnoli ,  John Robinson

    发明人： Jurg Zumbrunn ,  Steven Demarco ,  Sergio Lociuro ,  Daniel Obrecht ,  Barbara Romagnoli ,  John Robinson

    IPC分类号： A61K38/12 ,  C07K7/64

    CPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/001

    摘要： Template-fixed β-hairpin peptidomimetics of the General Formula (I); wherein Z1 and Z2 are template-fixed chains of 4 and 6 or 5 and 7 α-amino acid residues which, depending on their positions in the chain are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to prevent or to reduce HIV infections or to inhibit the growth of cancer cells or to inhibit inflammation. They can be used as medicaments to treat or prevent HIV infections and/or cancer or inflammatory disorders. These β-sheet peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

    摘要翻译： 通式（I）的模板固定的β-发夹肽模拟物; 其中Z 1和Z 2是4和6或5和7个α-氨基酸残基的模板固定链，根据其在链中的位置是Gly， 或Pro，或某些类型，其作为上述公式中的其余符号在说明书和权利要求书及其盐中定义，具有预防或减少HIV感染或抑制癌细胞生长或 以抑制炎症。 它们可用作治疗或预防艾滋病毒感染和/或癌症或炎性疾病的药物。 这些β-折叠肽模拟物可以通过基于混合固相和溶液相合成策略的方法制造。

    Medical Component Securement Device
    6.
    发明申请
    Medical Component Securement Device 审中-公开

    公开(公告)号：US20190015636A1

    公开(公告)日：2019-01-17

    申请号：US16136798

    申请日：2018-09-20

    申请人： John Robinson

    发明人： John Robinson

    IPC分类号： A61M25/02

    摘要： A medical component securement device includes a strap and a first medical component holder attached to the strap. The strap includes a number of openings spaced along the length of the strap that enables one or more auxiliary medical component holders to be removably attached to the strap. The first medical component holder may include two members that pivot about a pivot axis to open and close the first medical component holder.

    Apparatus for Distributing Short-Range Wireless Signals using an Interconnection Protocol for Electronic Devices
    7.
    发明申请
    Apparatus for Distributing Short-Range Wireless Signals using an Interconnection Protocol for Electronic Devices 审中-公开

    公开(公告)号：US20180338331A1

    公开(公告)日：2018-11-22

    申请号：US15601413

    申请日：2017-05-22

    申请人： David R. Hall ,  Mark Hall ,  John Robinson ,  Joe Fox

    发明人： David R. Hall ,  Mark Hall ,  John Robinson ,  Joe Fox

    IPC分类号： H04W76/02 ,  H04W4/00 ,  H04B7/04 ,  H04L29/08 ,  H04W56/00

    摘要： An apparatus for distributing data using a short-range wireless interconnection protocol for electronic devices includes a processor communicatively connected, using a communication bus, to a number of originator antennas, each of the number of originator antennas communicating with an originating device, a plurality of device antennas, communicatively connected to the communication bus, each of the plurality of device antennas communicating with a number of client devices, and a non-transitory storage medium. The non-transitory storage medium includes a receive module, a session identify module, and a send module. The receive module receives a data packet using one of the number of originator antennas. The session identify module identifies at least one communication session with at least one remote device associated with one of the plurality of device antennas. The send module sends the data packet to the at least one remote device associated with one of the plurality of device antennas.