发明申请
- 专利标题： V-like domain binding molecules
- 专利标题（中）： V型结构域结合分子
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申请号： US11588966申请日： 2006-10-27
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公开(公告)号： US20070065431A1公开(公告)日： 2007-03-22
- 发明人: Gregory Coia , Maria Galanis , Peter Hudson , Robert Irving , Stewart Nuttall
- 申请人： Gregory Coia , Maria Galanis , Peter Hudson , Robert Irving , Stewart Nuttall
- 优先权： AUPP2210 19980306
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C40B40/08 ; C40B30/06 ; G01N33/53 ; C07H21/04 ; C12P21/06
摘要：
The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
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