发明申请
US20070073064A1 Method for producing aminopyrrolidine derivatives and intermediate compounds
审中-公开
制备氨基吡咯烷衍生物和中间体化合物的方法
- 专利标题： Method for producing aminopyrrolidine derivatives and intermediate compounds
- 专利标题（中）： 制备氨基吡咯烷衍生物和中间体化合物的方法
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申请号： US10574688申请日： 2004-10-07
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公开(公告)号： US20070073064A1公开(公告)日： 2007-03-29
- 发明人: Takumi Takeyasu , Yoshinori Sato , Minoru Imai , Mitsuru Sakai , Kenji Manabe , Yoshiyuki Matsumoto , Susumu Takeuchi , Asahi Kawana , Masahiro Koga , Mitsuharu Asahita
- 申请人： Takumi Takeyasu , Yoshinori Sato , Minoru Imai , Mitsuru Sakai , Kenji Manabe , Yoshiyuki Matsumoto , Susumu Takeuchi , Asahi Kawana , Masahiro Koga , Mitsuharu Asahita
- 申请人地址： JP Tokyo 100-0011
- 专利权人： TEIJIN PHARMA LIMITED
- 当前专利权人： TEIJIN PHARMA LIMITED
- 当前专利权人地址： JP Tokyo 100-0011
- 优先权： JP2003-349318 20031008; JP2003-350441 20031009; JP2003-350439 20031009
- 国际申请： PCT/JP04/15186 WO 20041007
- 主分类号： C07D403/02
- IPC分类号： C07D403/02
摘要：
There is provided an industrial production method of an aminopyrrolidine derivative having chemokine receptor antagonist activity represented by the following formula, a synthetic intermediate thereof and a production method thereof: wherein R11 is H, C1-C6 alkyl or C2-C7 alkanoyl; R12, R14, R15, R16 and R17 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy, hydroxyl or C2-C7 alkoxycarbonyl; R23, R24, R25 and R26 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy or hydroxyl; and R3 is H or C1-C6 alkyl.