The present invention relates generally to an optical interconnection module for vertical optical coupling and a method of manufacturing the optical interconnection module. The optical interconnection module includes an optical waveguide. The optical waveguide includes substrate on which electrode pads and a predetermined circuit pattern are formed; a light source unit provided on the substrate and configured to generate an optical signal and emit the signal to an outside; an optical detection unit for receiving the optical signal from the light source unit and converting the optical signal into an electric signal; drive units provided on the substrate and configured to drive the light source unit and the light detection unit in response to electric signals supplied through the electrode pads; and a cladding layer, a core layer layered on the cladding layer, and an elliptical reflecting mirror surface placed on an end of the core layer facing the light source unit.