- 专利标题: Recombinant production of mixtures of antibodies
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申请号: US11593279申请日: 2006-11-06
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公开(公告)号: US20070077624A1公开(公告)日: 2007-04-05
- 发明人: Patrick Van Berkel , Ronald Brus , Ton Logtenberg , Abraham Bout
- 申请人: Patrick Van Berkel , Ronald Brus , Ton Logtenberg , Abraham Bout
- 申请人地址: NL Leiden
- 专利权人: Crucell Holland B.V.
- 当前专利权人: Crucell Holland B.V.
- 当前专利权人地址: NL Leiden
- 优先权: EP02077953.4 20020718; WOPCT/EP03/50201 20030527
- 主分类号: C12P21/08
- IPC分类号: C12P21/08 ; C07H21/04 ; C12N15/00 ; C12P21/06 ; C12N5/06 ; C07K16/18
摘要:
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
公开/授权文献
- US07429486B2 Recombinant production of mixtures of antibodies 公开/授权日:2008-09-30
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