Invention Application
- Patent Title: Recombinant proteins from filoviruses and their use
- Patent Title (中): 来自filoviruses的重组蛋白及其用途
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Application No.: US11545093Application Date: 2006-10-05
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Publication No.: US20070082011A1Publication Date: 2007-04-12
- Inventor: Axel Lehrer , David Clements , Tom Humphreys
- Applicant: Axel Lehrer , David Clements , Tom Humphreys
- Assignee: HAWAII BIOTECH, INC.
- Current Assignee: HAWAII BIOTECH, INC.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/12

Abstract:
Filovirus subunit protein immunogens are produced using a recombinant expression system and combined with one or more adjuvants in immunogenic formulations. The subunit proteins include GP95, GP-FL, VP40, VP24, and NP derived from Ebola Virus and Marburg Virus. Adjuvants include saponins, emulsions, alum, and dipeptidyl peptidase inhibitors. The disclosed immunogenic formulations are effective in inducing strong antibody responses directed against individual Filovirus proteins and intact Filovirus particles as well as stimulating cell-mediated immune responses to the Filoviruses.
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