发明申请
- 专利标题: Novel polymers for delivering nitric oxide in vivo
- 专利标题(中): 用于在体内递送一氧化氮的新型聚合物
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申请号: US11500180申请日: 2006-08-07
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公开(公告)号: US20070088435A1公开(公告)日: 2007-04-19
- 发明人: Jonathan Stamler , Eric Toone , Richard Stack
- 申请人: Jonathan Stamler , Eric Toone , Richard Stack
- 主分类号: A61F2/02
- IPC分类号: A61F2/02 ; A61F13/00
摘要:
Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
公开/授权文献
- US07417109B2 Polymers for delivering nitric oxide in vivo 公开/授权日:2008-08-26