发明申请
US20070093536A1 Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto
审中-公开
与其对应的抗糖尿病和新型抗糖尿病不育的靶蛋白
- 专利标题： Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto
- 专利标题（中）： 与其对应的抗糖尿病和新型抗糖尿病不育的靶蛋白
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申请号： US10569791申请日： 2004-11-16
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公开(公告)号： US20070093536A1公开(公告)日： 2007-04-26
- 发明人: Yorimasa Suwa , Tsuyoshi Yamada , Hironori Osaki , Minoru Furuya
- 申请人： Yorimasa Suwa , Tsuyoshi Yamada , Hironori Osaki , Minoru Furuya
- 优先权： JP2003-402164 20031201
- 国际申请： PCT/JP04/16996 WO 20041116
- 主分类号： A61K31/426
- IPC分类号： A61K31/426 ; C07K14/705 ; C07H21/04 ; C07D277/34
摘要：
The present invention is intended to elucidate a molecular target of an antidiabetic such as a thiazolidine derivative. The present invention provides a screening method for an antidiabetic, comprising the steps of: bringing a candidate substance to be screened into contact with a protein represented by the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 with the deletion, substitution, addition, or insertion of one or plural amino acids and interacting with the antidiabetic; and detecting the interaction between the candidate substance and the protein.