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13 条记录 (耗时 0.044 秒)

    Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto
    6.
    发明申请
    Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto 审中-公开
    与其对应的抗糖尿病和新型抗糖尿病不育的靶蛋白

    公开(公告)号：US20070093536A1

    公开(公告)日：2007-04-26

    申请号：US10569791

    申请日：2004-11-16

    申请人： Yorimasa Suwa ,  Tsuyoshi Yamada ,  Hironori Osaki ,  Minoru Furuya

    发明人： Yorimasa Suwa ,  Tsuyoshi Yamada ,  Hironori Osaki ,  Minoru Furuya

    IPC分类号： A61K31/426 ,  C07K14/705 ,  C07H21/04 ,  C07D277/34

    CPC分类号： C07K14/47 ,  G01N33/6893 ,  G01N2800/042

    摘要： The present invention is intended to elucidate a molecular target of an antidiabetic such as a thiazolidine derivative. The present invention provides a screening method for an antidiabetic, comprising the steps of: bringing a candidate substance to be screened into contact with a protein represented by the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 with the deletion, substitution, addition, or insertion of one or plural amino acids and interacting with the antidiabetic; and detecting the interaction between the candidate substance and the protein.

    摘要翻译： 本发明旨在阐明抗糖尿病药如噻唑烷衍生物的分子靶标。 本发明提供一种抗糖尿病的筛选方法，其特征在于，包括以下步骤：使候选物质与下列（a）或（b）所示蛋白质接触：（a）含有氨基酸序列 由SEQ ID NO：2表示; 或者（b）包含来源于SEQ ID NO：2所示的氨基酸序列的氨基酸序列的蛋白质与一个或多个氨基酸的缺失，取代，添加或插入并与抗糖尿病相互作用的蛋白质; 并检测候选物质与蛋白质之间的相互作用。

    Method of inhibiting nonspecific interaction between molecules on solid phase support
    9.
    发明申请
    Method of inhibiting nonspecific interaction between molecules on solid phase support 有权
    抑制固相载体上分子之间非特异性相互作用的方法

    公开(公告)号：US20060177943A1

    公开(公告)日：2006-08-10

    申请号：US10522716

    申请日：2003-07-30

    申请人： Akito Tanaka ,  Tomohiro Terada ,  Tsuruki Tamura ,  Takaaki Shiyama ,  Akira Yamazaki ,  Minoru Furuya ,  Masayuki Haramura

    发明人： Akito Tanaka ,  Tomohiro Terada ,  Tsuruki Tamura ,  Takaaki Shiyama ,  Akira Yamazaki ,  Minoru Furuya ,  Masayuki Haramura

    IPC分类号： G01N33/543 ,  C07C229/64

    CPC分类号： C08G65/33396 ,  G01N33/54393

    摘要： The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

    摘要翻译： 本发明提供了抑制分子之间非特异性相互作用的方法，其特征在于在将分子固定在固相载体上并分析分子与与固相分子特异性相互作用的分子之间的特异性相互作用的方法 调节固相载体中固相表面的疏水性，特别是在将分子固定在固相载体上时，亲水间隔物被嵌入，该方法可以抑制分子之间的非特异性相互作用 ，并减少对固相的非特异性吸附。

    Vitamin D.sub.3 derivative and treating agent for inflammatory respiratory disease using same
    10.
    发明授权
    Vitamin D.sub.3 derivative and treating agent for inflammatory respiratory disease using same 失效
    维生素D3衍生物和用于炎性呼吸系统疾病的治疗剂

    公开(公告)号：US6028208A

    公开(公告)日：2000-02-22

    申请号：US242665

    申请日：1999-02-22

    申请人： Qingzhi Gao ,  Kenji Manabe ,  Minoru Furuya ,  Manabu Chokki ,  Hiroaki Mitsuhashi ,  Seiichi Ishizuka ,  Tadashi Kishimoto ,  Masayasu Tabe ,  Yasuji Sakuma ,  Atsuo Hazato ,  Hiroko Tanaka

    发明人： Qingzhi Gao ,  Kenji Manabe ,  Minoru Furuya ,  Manabu Chokki ,  Hiroaki Mitsuhashi ,  Seiichi Ishizuka ,  Tadashi Kishimoto ,  Masayasu Tabe ,  Yasuji Sakuma ,  Atsuo Hazato ,  Hiroko Tanaka

    IPC分类号： C07C401/00 ,  A61K31/59

    CPC分类号： C07C401/00

    摘要： Provided are vitamin D.sub.3 derivatives expressed by the following general formula [1] ##STR1## [wherein, R.sub.1 and R.sub.2 are each a hydrogen atom, a trialkylsilyl group, an acetyl group, a methoxymethyl group, or a tetrahydropyranyl group; R.sub.3 and R.sub.4 are each a hydrogen atom, a hydroxyl group, an acyloxy group, an alkyloxy group, an alkylthio group or an alkyl group which is optionally substituted; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each a hydrogen atom, a hydroxyl group, an alkyl group or an acyloxy group; R.sub.9 is a hydrogen atom, a hydroxyl group, an alkyl group or an alkylthio group; R.sub.10 is a hydrogen atom, an alkyl group or an alkyloxy group; A and B are each a hydrogen atom, a hydroxyl group, or together express a single bond; X and Y express a carbonyl oxygen, or one of them is a hydrogen atom and the other is a hydroxyl group or an acyloxy group; n is an integer of 0 to 2; m is an integer of 0 to 2], and a method for manufacturing the derivatives.The compounds can be sued as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis and dermatitis.

    摘要翻译： PCT No.PCT / JP98 / 02813 Sec。 一九九九年二月二十二日 102（e）1999年2月22日PCT提交1998年6月24日PCT公布。 公开号WO98 / 58909 日期：1998年12月30日提供由以下通式[1]表示的维生素D3衍生物[其中，R1和R2各自为氢原子，三烷基甲硅烷基，乙酰基，甲氧基甲基或四氢吡喃基; R3和R4各自为氢原子，羟基，酰氧基，烷氧基，烷硫基或任选取代的烷基; R5，R6，R7和R8分别是氢原子，羟基，烷基或酰氧基; R9为氢原子，羟基，烷基或烷硫基; R 10是氢原子，烷基或烷氧基; A和B各自为氢原子，羟基，或一起表示单键; X和Y表示羰基氧，或者其中一个是氢原子，另一个是羟基或酰氧基; n为0〜2的整数， m为0〜2的整数]，以及该衍生物的制造方法。 这些化合物可以作为炎性呼吸系统疾病，恶性肿瘤，类风湿性关节炎，骨质疏松症，糖尿病，高血压，脱发，痤疮，牛皮癣和皮炎的治疗剂的活性成分。