The invention includes a delivery device for introducing a prosthesis beneath a tissue surface that includes an elongate body having a proximal end and a distal end, an opening on the elongate body, which is at least partially covered by a mesh, and a deployment lumen extending through the body that has a longitudinal axis and a distal end, wherein the distal end of the deployment lumen is positioned proximal of the opening. Also included are delivery systems and kits that include delivery devices of the invention. Further, an overtube for receiving an endoscope, that includes an elongate, flexible tubular body, having a proximal end and a distal end and a longitudinal axis, at least one lumen extending therethrough for receiving an endoscope, an opening on the body, in communication with the lumen, and a tissue limiting surface within the body aligned with the opening, formed at least in part by a mesh. Methods of using the devices, and kits are also included in the invention.