发明申请
- 专利标题: Novel bHLH type transcription factor genes
- 专利标题(中): 新型bHLH型转录因子基因
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申请号: US11592338申请日: 2006-11-03
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公开(公告)号: US20070105143A1公开(公告)日: 2007-05-10
- 发明人: Katsumi Fujimoto , Mei Shin , Yukio Kato
- 申请人: Katsumi Fujimoto , Mei Shin , Yukio Kato
- 专利权人: Chugai Seiyaku Kabushiki Kaisha, a Japanese corporation
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha, a Japanese corporation
- 优先权: JP11-233286 19990819
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; C07H21/04 ; C12P21/06 ; C12N9/12
摘要:
Human- and mouse-derived bHLH type transcription factors were isolated. These transcription factors shared homology with the transcription factor DEC1, the expression of which is induced in human cartilage cells when differentiated with cAMP. Thus, these isolated transcription factors are thought to be novel transcription factors belonging to the DEC1 subfamily. The transcription factors of the present invention are also homologous to mouse Stra13 and rat SHARP that are related to neurocyte differentiation. The transcription factors of the present invention may be used as tools for developing pharmaceutical agents for diseases related to the differentiation and proliferation of cells.
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