公开(公告)号：US20070105143A1

公开(公告)日：2007-05-10

申请号：US11592338

申请日：2006-11-03

申请人： Katsumi Fujimoto ,  Mei Shin ,  Yukio Kato

发明人： Katsumi Fujimoto ,  Mei Shin ,  Yukio Kato

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C07K14/4702 ,  C07K2319/00

摘要： Human- and mouse-derived bHLH type transcription factors were isolated. These transcription factors shared homology with the transcription factor DEC1, the expression of which is induced in human cartilage cells when differentiated with cAMP. Thus, these isolated transcription factors are thought to be novel transcription factors belonging to the DEC1 subfamily. The transcription factors of the present invention are also homologous to mouse Stra13 and rat SHARP that are related to neurocyte differentiation. The transcription factors of the present invention may be used as tools for developing pharmaceutical agents for diseases related to the differentiation and proliferation of cells.

摘要翻译： 分离人和小鼠衍生的bHLH型转录因子。 这些转录因子与转录因子DEC1共享同源性，当用cAMP分化时，其转录因子在人软骨细胞中被诱导。 因此，这些分离的转录因子被认为是属于DEC1亚家族的新型转录因子。 本发明的转录因子也与与神经细胞分化相关的小鼠Stra13和大鼠SHARP同源。 本发明的转录因子可用作开发用于与细胞分化和增殖有关的疾病的药物的工具。