发明申请
US20070122891A1 Methods for the Preparation, Isolation and Purification of Epothilone B, and X-Ray Crystal Structures of Epothilone B
有权
埃坡霉素B的制备，分离和纯化方法以及埃坡霉素B的X射线晶体结构
- 专利标题： Methods for the Preparation, Isolation and Purification of Epothilone B, and X-Ray Crystal Structures of Epothilone B
- 专利标题（中）： 埃坡霉素B的制备，分离和纯化方法以及埃坡霉素B的X射线晶体结构
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申请号： US11669268申请日： 2007-01-31
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公开(公告)号： US20070122891A1公开(公告)日： 2007-05-31
- 发明人: Daniel Benigni , Robert Stankavage , Shu-Jen Chiang , Hsing Hou , Bruce Eagan , Dennis Gu , David Hou , Les Mintzmyer , Thomas Tully , Brian Davis , Ivan Hargro , Mark Mascari , Gabriel Galvin , Gregory Stein , Cary McConlogue , Fahri Comezoglu
- 申请人： Daniel Benigni , Robert Stankavage , Shu-Jen Chiang , Hsing Hou , Bruce Eagan , Dennis Gu , David Hou , Les Mintzmyer , Thomas Tully , Brian Davis , Ivan Hargro , Mark Mascari , Gabriel Galvin , Gregory Stein , Cary McConlogue , Fahri Comezoglu
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： C12P17/00
- IPC分类号： C12P17/00 ; C12N1/20 ; C07D417/02
摘要：
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
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