发明申请
US20070129400A1 Modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity, and use thereof
有权
糖皮质激素受体,AP-1和/或NF-kB活性的调节剂及其用途
- 专利标题: Modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity, and use thereof
- 专利标题(中): 糖皮质激素受体,AP-1和/或NF-kB活性的调节剂及其用途
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申请号: US11451660申请日: 2006-06-13
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公开(公告)号: US20070129400A1公开(公告)日: 2007-06-07
- 发明人: Jingwu Duan , Zhonghui Lu , David Weinstein , Bin Jiang
- 申请人: Jingwu Duan , Zhonghui Lu , David Weinstein , Bin Jiang
- 主分类号: A61K31/4709
- IPC分类号: A61K31/4709 ; A61K31/4439 ; A61K31/428 ; A61K31/427 ; A61K31/416 ; C07D417/02 ; C07D403/02 ; C07D405/02 ; C07D409/02
摘要:
Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or an enantiomer, a diastereomer, a pharmaceutically acceptable salt, or hydrate thereof, where J is selected from NR1 or C(R4)(R4a); K is selected from NR2 or C(R5)(R5a); L is selected from NR3 or C(R6)(R6a); and A, X, Y, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R8, R10, R11, and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
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