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发明申请
US20070134243A1 Antibody drug conjugates and methods 审中-公开
抗体药物偶联物和方法

Antibody drug conjugates and methods
摘要：
The invention relates to antibody drug conjugate (ADC) compounds represented by Formula I: Ab-(L-D)p  I where one or more 1,8 bis-naphthalimide drug moieties (D) having Formulas IIa and IIb are covalently linked by a linker (L) to an antibody (Ab). The invention also relates to pharmaceutical compositions comprising an effective amount of a Formula I ADC for treatment of hyperproliferative disorders and other disorders. The invention also relates to methods for killing or inhibiting the multiplication of a tumor cell or cancer cell including administering to a patient an effective amount of a Formula I ADC.
摘要（中）：

本发明涉及由式I表示的抗体药物偶联物（ADC）化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> Ab-（LD） > I <？in-line-formula description =“In-line Formulas”end =“tail”？>其中一个或多个具有式IIa和IIb的1,8-双萘二甲酰亚胺药物部分（D）通过连接体共价连接 （L）至抗体（Ab）。 本发明还涉及药物组合物，其包含有效量的用于治疗过度增殖性疾病和其它疾病的式IADC。 本发明还涉及杀死或抑制肿瘤细胞或癌细胞增殖的方法，包括向患者施用有效量的式I ADC。

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