发明申请
US20070142397A2 PHENYPIPERAZINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION
审中-公开
具有局部多巴胺-D2受体激动剂和丝氨酸蛋白酶抑制剂组合的苯并吡啶衍生物
- 专利标题： PHENYPIPERAZINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION
- 专利标题（中）： 具有局部多巴胺-D2受体激动剂和丝氨酸蛋白酶抑制剂组合的苯并吡啶衍生物
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申请号： US11294615申请日： 2005-12-06
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公开(公告)号： US20070142397A2公开(公告)日： 2007-06-21
- 发明人: Roelof Feenstra , Axel Stoit , Jan-Willem Terpstra , Maria Pras-Raves , Andrew McCreary , Bernard Van Vliet , Mayke Hesselink , Cornelis Kruse , Gustaaf Van Scharrenburg
- 申请人： Roelof Feenstra , Axel Stoit , Jan-Willem Terpstra , Maria Pras-Raves , Andrew McCreary , Bernard Van Vliet , Mayke Hesselink , Cornelis Kruse , Gustaaf Van Scharrenburg
- 申请人地址： NL Weesp 1381 CP
- 专利权人： SOLVAY PHARMECEUTICALS B.V.
- 当前专利权人： SOLVAY PHARMECEUTICALS B.V.
- 当前专利权人地址： NL Weesp 1381 CP
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D413/14
摘要：
The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification.
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