The coating composition which coats the biologically active substance includes at least one protective material selected from the group consisting of a hardened animal fat, a hardened vegetable oil, a linear or branched, saturated or unsaturated aliphatic monocarboxylic acid having 12 to 22 carbon atoms, a fatty acid ester, and a wax group; lecithin; and at least one preservative selected from a propionic acid or its salt, a sorbic acid or its salt, a benzoic acid or its salt, a dehydroacetic acid or its salt, parahydroxybenzoic acid esters, an imazalil, a thiabendazole, an orthophenyl phenol, an orthophenyl phenol natrium, and a diphenyl.