A vessel wound closure device that separately deploys a suture and a snare within a vessel to produce a stitch across a puncture site of a vessel. Once deployed within the vessel, the suture is captured within the snare, withdrawn, and then secured to provide a stitch across the puncture site of the vessel. The vessel wound closure device minimizes the amount of material introduced or left within the vessel or between edges of the puncture site, maximizes healing of the puncture site, and renders the vessel amenable to subsequent interventional or therapeutic procedures at or near the same site.