发明申请
- 专利标题: 4-Carbox pyrazole derivatives useful as anti-viral agents
- 专利标题(中): 用作抗病毒剂的4-羧基吡唑衍生物
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申请号: US10599346申请日: 2005-03-22
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公开(公告)号: US20070167507A1公开(公告)日: 2007-07-19
- 发明人: Gianpaolo Bravi , John Corfield , Richard Grimes , Rossella Guidetti , Victoria Lucy Lovegrove , Jacqueline Mordaunt , Pritom Shah , Martin Slater
- 申请人: Gianpaolo Bravi , John Corfield , Richard Grimes , Rossella Guidetti , Victoria Lucy Lovegrove , Jacqueline Mordaunt , Pritom Shah , Martin Slater
- 申请人地址: GB MIDDLESEX UB6 0NN US PA PHILADELPHIA 19101
- 专利权人: GLAXO GROUP LIMITED,SMITHKLINE BEECHAM CORPORATION
- 当前专利权人: GLAXO GROUP LIMITED,SMITHKLINE BEECHAM CORPORATION
- 当前专利权人地址: GB MIDDLESEX UB6 0NN US PA PHILADELPHIA 19101
- 优先权: GB0406916.7 20040326; GB0406918.3 20040326; GB0423000.9 20041015; GB0423001.7 20041015
- 国际申请: PCT/GB05/01071 WO 20050322
- 主分类号: A61K31/416
- IPC分类号: A61K31/416 ; A61K31/4152 ; C07D405/02 ; C07D409/02
摘要:
Novel antiviral compounds of Formula (I): wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or —C5-9cycloalkyl, each of which may be optionally substituted; R2 represents substituted phenyl, or —(CH2)nC5-7cycloalkyl optionally substituted on the cycloalkyl; R3 represents heterocyclyl or heteroaryl; optionally substituted phenyl or optionally substituted —C1-6alkyl; R4 represents hydrogen; and salts, solvates and esters thereof processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.
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