发明申请
- 专利标题： Active hedgehog protein conjugate
- 专利标题（中）： 活性刺猬蛋白结合物
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申请号： US11645014申请日： 2006-12-22
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公开(公告)号： US20070191274A1公开(公告)日： 2007-08-16
- 发明人: Angelika Esswein , Kurt Lang , Petra Rueger , Tilman Seytter
- 申请人： Angelika Esswein , Kurt Lang , Petra Rueger , Tilman Seytter
- 优先权： EP98107911.4 19980430; EP98116733.1 19980903
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/47 ; A61K31/727 ; A61K31/185
摘要：
A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
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