公开(公告)号：US06468978B1

公开(公告)日：2002-10-22

申请号：US09301199

申请日：1999-04-28

申请人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

发明人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

IPC分类号： A61K3817

CPC分类号： A61K31/185 ,  A61K31/727 ,  A61K38/00 ,  C07K14/47

摘要： A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

摘要翻译： 一种刺猬蛋白缀合物，其特征在于其包含：a）由10至30个疏水氨基酸和/或氨基酸组成的多肽，其形成跨膜螺旋并带正电荷，b）1至4个脂族，饱和或不饱和的烃残基， 链长为10至24个C原子并具有疏水作用，或c）与猬蛋白共价结合的疏水性硫代化合物，并且其具有几倍增加的活性并且适于作为药剂。

公开(公告)号：US20070191274A1

公开(公告)日：2007-08-16

申请号：US11645014

申请日：2006-12-22

申请人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

发明人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

IPC分类号： A61K38/17 ,  C07K14/47 ,  A61K31/727 ,  A61K31/185

CPC分类号： A61K31/185 ,  A61K31/727 ,  A61K38/00 ,  C07K14/47

摘要： A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

摘要翻译： 一种刺猬蛋白缀合物，其特征在于其包含：a）由10至30个疏水氨基酸和/或氨基酸组成的多肽，其形成跨膜螺旋并带正电荷，b）1至4个脂族，饱和或不饱和的烃残基， 链长为10至24个C原子并具有疏水作用，或c）与猬蛋白共价结合的疏水性硫代化合物，并且其具有几倍增加的活性并且适于作为药剂。

公开(公告)号：US20050148510A1

公开(公告)日：2005-07-07

申请号：US10961982

申请日：2004-10-08

申请人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

发明人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  C07K14/435 ,  C07K14/47 ,  A61K38/17 ,  C07H21/04

CPC分类号： A61K31/185 ,  A61K31/727 ,  A61K38/00 ,  C07K14/47

摘要： A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

摘要翻译： 一种刺猬蛋白缀合物，其特征在于其包含：a）由10至30个疏水氨基酸和/或氨基酸组成的多肽，其形成跨膜螺旋并带正电荷，b）1至4个脂族，饱和或不饱和的烃残基， 链长为10至24个C原子并具有疏水作用，或c）与猬蛋白共价结合的疏水性硫代化合物，并且其具有几倍增加的活性并且适于作为药剂。

公开(公告)号：US06818623B2

公开(公告)日：2004-11-16

申请号：US10278060

申请日：2002-10-21

申请人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

发明人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

IPC分类号： A61K3817

CPC分类号： A61K31/185 ,  A61K31/727 ,  A61K38/00 ,  C07K14/47

摘要： A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

摘要翻译： 一种刺猬蛋白缀合物，其特征在于其包含：a）由10至30个疏水氨基酸和/或氨基酸组成的多肽，其形成跨膜螺旋并带正电荷，b）1至4个脂族，饱和或不饱和的烃残基， 链长为10至24个C原子并具有疏水作用，或c）与猬蛋白共价结合的疏水性硫代化合物，并且其具有几倍增加的活性并且适于作为药剂。

公开(公告)号：US06994990B1

公开(公告)日：2006-02-07

申请号：US09198975

申请日：1998-11-24

申请人： Kurt Lang ,  Ulrike Leser ,  Tilman Seytter

发明人： Kurt Lang ,  Ulrike Leser ,  Tilman Seytter

IPC分类号： C12P21/06

CPC分类号： C07K14/46 ,  A61K38/00 ,  C07K2319/02 ,  C12N2799/026

摘要： The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly active modified hedgehog proteins are also provided.