发明申请
US20070196354A1 Method of treating diabetes by inhibiting degradation of at least one of crebl1, atf6, and hnf-4 alpha by htra
审中-公开
通过抑制htra中crebl1，atf6和hnf-4α中的至少一种降解来治疗糖尿病的方法
- 专利标题： Method of treating diabetes by inhibiting degradation of at least one of crebl1, atf6, and hnf-4 alpha by htra
- 专利标题（中）： 通过抑制htra中crebl1，atf6和hnf-4α中的至少一种降解来治疗糖尿病的方法
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申请号： US10563073申请日： 2004-09-30
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公开(公告)号： US20070196354A1公开(公告)日： 2007-08-23
- 发明人: Hirofumi Doi , Ken Saito
- 申请人： Hirofumi Doi , Ken Saito
- 优先权： JP2003-342587 20030930
- 国际申请： PCT/JP04/14377 WO 20040930
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; C12Q1/37
摘要：
The present invention found the interaction of CREBL1 and HNF-4α with HtrA2 and revealed for the first time that CREBL1, ATF6, and HNF-4α are degraded by active HtrA2. In addition, the present invention provides a means for inhibiting the degradation of at least one of CREBL1, ATF6, and HNF-4α, comprising inhibiting the function of HtrA2; a means for preventing and/or treating diabetes, comprising inhibiting the degradation by HtrA2 of at least one of CREBL1, ATF6, and HNF-4α; a means for preventing cell death (for example, pancreatic β cell death), comprising inhibiting the degradation by HtrA2 of CREBL1 and/or ATF6; a means for preventing and/or treating type 2 diabetes, comprising inhibiting the degradation by HtrA2 of HNF-4α; and a reagent kit.
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