A method of removing breast tissue may include steps of providing a tissue cutting device having a shaft, a tissue collection element and a cutting element, the cutting element being movable from a collapsed position to an expanded position. The tissue cutting device may be introduced into the patient's breast through a first incision with the cutting element in the collapsed position and the cutting element may be expanded. The cutting element may then be moved through breast tissue to cut around the tissue to be removed. The tissue cut by the cutting element may be positioned into the tissue collection element, and the tissue collection element may be removed through a second incision that is different from the first incision.