发明申请
US20070207139A1 ENHANCING THE EFFECT OF THERAPEUTIC PROTEINS ON THE CENTRAL NERVOUS SYSTEM
审中-公开
治疗性蛋白质对中枢神经系统的影响
- 专利标题： ENHANCING THE EFFECT OF THERAPEUTIC PROTEINS ON THE CENTRAL NERVOUS SYSTEM
- 专利标题（中）： 治疗性蛋白质对中枢神经系统的影响
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申请号： US11614970申请日： 2006-12-21
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公开(公告)号： US20070207139A1公开(公告)日： 2007-09-06
- 发明人: Shunji Tomatsu , Adriana Montano , Tatsuo Nishioka , Jeffrey Grubb , William Sly , Monica Gutierrez , Amelia Rodriguez
- 申请人： Shunji Tomatsu , Adriana Montano , Tatsuo Nishioka , Jeffrey Grubb , William Sly , Monica Gutierrez , Amelia Rodriguez
- 申请人地址： US MO St. Louis
- 专利权人： Saint Louis University, a non-profit organization
- 当前专利权人： Saint Louis University, a non-profit organization
- 当前专利权人地址： US MO St. Louis
- 主分类号： A61K38/47
- IPC分类号： A61K38/47 ; C12N9/42
摘要：
The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a method of enhancing the effect of a polypeptide or protein on the central nervous system by the attachment of a short acidic amino acid sequence. Specifically the inventors disclose the attachment of a 4-15 acidic amino acid sequence to human β-glucuronidase by construction of a fusion protein. This molecule is useful in the treatment of type VII mucopolysaccharidosis when administered to a patient.
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