发明申请
US20070207510A1 Methods and compounds for lymphoma cell detection and isolation
审中-公开
用于淋巴瘤细胞检测和分离的方法和化合物
- 专利标题： Methods and compounds for lymphoma cell detection and isolation
- 专利标题（中）： 用于淋巴瘤细胞检测和分离的方法和化合物
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申请号： US11709917申请日： 2007-02-21
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公开(公告)号： US20070207510A1公开(公告)日： 2007-09-06
- 发明人: Thomas Kipps , Tetsuya Fukuda , Tomoyuki Endo
- 申请人： Thomas Kipps , Tetsuya Fukuda , Tomoyuki Endo
- 专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; C07K16/30
摘要：
Compositions comprising a purified, isolated antibody, humanized antibodies and precipitates directed against ROR-1, wherein the antibody binds ROR-1 with moderate to high affinity. The compositions may be used for detecting and isolating an amount of ROR-1 in a subject sample, and to evaluate the appearance, status, course, or treatment of a ROR-1 cancer in a subject. The ROR-1 antibodies are especially useful in identifying lymphomas and ademocarcinomas. Vaccines and related methods for protecting a subject against diseases that involve expression of ROR-1 are also provided.
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