Invention Application
- Patent Title: Tao Kinase Modulators And Method Of Use
- Patent Title (中): 陶激酶调节剂及其使用方法
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Application No.: US10576932Application Date: 2004-10-22
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Publication No.: US20070208166A1Publication Date: 2007-09-06
- Inventor: Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
- Applicant: Deborah Baly , Adam Galan , Mohamed Ibrahim , Christopher Jaeger , Patrick Kearney , James Leahy , Gary Lewis , Kirk McMillan , Robin Noguchi , John Nuss , Jason Parks , Kevin Schnepp , Xian Shi , Matthew Williams , Wei Xu , Wentao Zhang
- Applicant Address: US CA South San Franciso 94083-0511
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Franciso 94083-0511
- International Application: PCT/US04/35469 WO 20041022
- Main IPC: C07D471/02
- IPC: C07D471/02
Abstract:
The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
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