公开(公告)号：US20070208166A1

公开(公告)日：2007-09-06

申请号：US10576932

申请日：2004-10-22

申请人： Deborah Baly ,  Adam Galan ,  Mohamed Ibrahim ,  Christopher Jaeger ,  Patrick Kearney ,  James Leahy ,  Gary Lewis ,  Kirk McMillan ,  Robin Noguchi ,  John Nuss ,  Jason Parks ,  Kevin Schnepp ,  Xian Shi ,  Matthew Williams ,  Wei Xu ,  Wentao Zhang

发明人： Deborah Baly ,  Adam Galan ,  Mohamed Ibrahim ,  Christopher Jaeger ,  Patrick Kearney ,  James Leahy ,  Gary Lewis ,  Kirk McMillan ,  Robin Noguchi ,  John Nuss ,  Jason Parks ,  Kevin Schnepp ,  Xian Shi ,  Matthew Williams ,  Wei Xu ,  Wentao Zhang

IPC分类号： C07D471/02

CPC分类号： C07C237/22 ,  C07C275/16 ,  C07C275/34 ,  C07C2602/10 ,  C07D207/16 ,  C07D209/20 ,  C07D209/42 ,  C07D209/44 ,  C07D213/56 ,  C07D213/75 ,  C07D215/48 ,  C07D215/54 ,  C07D217/06 ,  C07D217/22 ,  C07D233/56 ,  C07D233/58 ,  C07D263/32 ,  C07D277/46 ,  C07D277/66 ,  C07D277/82 ,  C07D295/155 ,  C07D295/185 ,  C07D319/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

摘要翻译： 本发明提供了用于抑制激酶的化合物和方法，例如TAO族的那些，更具体地是KIAA1361，TAO和JIK激酶。 本发明提供用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节与上述细胞活性变化相关的激酶受体信号转导途径，本发明包括含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法 。

公开(公告)号：US20070275952A1

公开(公告)日：2007-11-29

申请号：US10549300

申请日：2004-03-19

申请人： Lynne Bannen ,  S. Brown ,  Wei Cheng ,  Vasu Jammalamadaka ,  John Nuss ,  Morrison Mac ,  Jason Parks ,  Matthew Williams ,  Wei Xu ,  Atwood Cheung ,  Lisa Dalrymple ,  Sergey Epshteyn ,  Mohamed Ibrahim ,  James Leahy ,  Gary Lewis ,  Robin Noguchi ,  Larry Mann ,  Brian Ridway ,  Joan Sangalang ,  Kevin Schnepp ,  Xian Shi ,  Richard Khoury

发明人： Lynne Bannen ,  S. Brown ,  Wei Cheng ,  Vasu Jammalamadaka ,  John Nuss ,  Morrison Mac ,  Jason Parks ,  Matthew Williams ,  Wei Xu ,  Atwood Cheung ,  Lisa Dalrymple ,  Sergey Epshteyn ,  Mohamed Ibrahim ,  James Leahy ,  Gary Lewis ,  Robin Noguchi ,  Larry Mann ,  Brian Ridway ,  Joan Sangalang ,  Kevin Schnepp ,  Xian Shi ,  Richard Khoury

IPC分类号： A61K31/41 ,  A61K31/44 ,  A61K31/445 ,  A61K31/497 ,  A61K31/535 ,  A61K31/551 ,  A61P35/00 ,  C07D243/08 ,  C07D285/10 ,  C07D401/14 ,  C07D413/00 ,  C07D417/02 ,  C12N5/00 ,  C12Q1/00

CPC分类号： A61K31/496 ,  C07D213/75 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

公开(公告)号：US20110263544A1

公开(公告)日：2011-10-27

申请号：US13122239

申请日：2009-10-07

申请人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Hiroyuki Tsuruoka ,  Kazumasa Aoki ,  Masatoshi Honzumi ,  Yusuke Asoh ,  Keiji Saito ,  Tsuyoshi Homma

发明人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Hiroyuki Tsuruoka ,  Kazumasa Aoki ,  Masatoshi Honzumi ,  Yusuke Asoh ,  Keiji Saito ,  Tsuyoshi Homma

IPC分类号： A61K31/635 ,  A61K31/402 ,  A61P9/10 ,  C12N5/071 ,  A61P13/12 ,  A61P5/42 ,  A61P7/10 ,  C07D207/34 ,  A61P9/12

CPC分类号： C07D207/34

摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.

摘要翻译： 本发明包括用于预防和/或治疗心血管疾病，肾病，纤维化，原发性醛固酮增多症或水肿的化合物。 该化合物具有以下通式（I）：其中R 1表示C 1 -C 3烷基; R2表示羟基-C1-C4烷基等; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4表示氢原子，卤代基等，-R5表示氨磺酰基或C1-C3烷基磺酰基; R6表示氢原子，卤代基等]或上述的N-氧化物，阻转异构体或上述的药学上可接受的盐。

公开(公告)号：US08642640B2

公开(公告)日：2014-02-04

申请号：US13122239

申请日：2009-10-07

申请人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Hiroyuki Tsuruoka ,  Kazumasa Aoki ,  Masatoshi Honzumi ,  Yusuke Asoh ,  Keiji Saito ,  Tsuyoshi Homma

发明人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Hiroyuki Tsuruoka ,  Kazumasa Aoki ,  Masatoshi Honzumi ,  Yusuke Asoh ,  Keiji Saito ,  Tsuyoshi Homma

IPC分类号： A61K31/40 ,  C07D207/08

CPC分类号： C07D207/34

摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.

摘要翻译： 本发明包括用于预防和/或治疗心血管疾病，肾病，纤维化，原发性醛固酮增多症或水肿的化合物。 该化合物具有以下通式（I）：其中R 1表示C 1 -C 3烷基; R2表示羟基-C1-C4烷基等; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4表示氢原子，卤代基等，-R5表示氨磺酰基或C1-C3烷基磺酰基; R6表示氢原子，卤代基等]或上述的N-氧化物，阻转异构体或上述的药学上可接受的盐。

公开(公告)号：US08487117B2

公开(公告)日：2013-07-16

申请号：US13122147

申请日：2009-10-07

申请人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Kazumasa Aoki ,  Hiroyuki Tsuruoka ,  Noriyuki Hayashi ,  Tsuyoshi Homma

发明人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Kazumasa Aoki ,  Hiroyuki Tsuruoka ,  Noriyuki Hayashi ,  Tsuyoshi Homma

IPC分类号： C07D207/30 ,  A61K31/40

CPC分类号： C07D207/34

摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a 2-hydroxy-C4-C6 alkyl group; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like; R5 represents a C1-C3 alkyl group; and R6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.

摘要翻译： 本发明包括用于预防和/或治疗心血管疾病的化合物。 该化合物是由以下通式（I）表示的化合物的阻转异构体：其中R1表示C1-C3烷基; R2表示2-羟基-C4-C6烷基; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4代表氢原子，卤代基等; R5代表C1-C3烷基; R6表示氢原子，卤代基等]或它们的阻转异构体。

公开(公告)号：US20110263673A1

公开(公告)日：2011-10-27

申请号：US13122147

申请日：2009-10-07

申请人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Kazumasa Aoki ,  Hiroyuki Tsuruoka ,  Noriyuki Hayashi ,  Tsuyoshi Homma

发明人： John Nuss ,  Matthew Williams ,  Raju Mohan ,  Richard Martin ,  Tie-Lin Wang ,  Kazumasa Aoki ,  Hiroyuki Tsuruoka ,  Noriyuki Hayashi ,  Tsuyoshi Homma

IPC分类号： A61K31/40 ,  C12N5/071 ,  A61P3/10 ,  A61P9/10 ,  C07D207/34 ,  A61P9/00

CPC分类号： C07D207/34

摘要： The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a 2-hydroxy-C4-C6 alkyl group; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like; R5 represents a C1-C3 alkyl group; and R6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.

摘要翻译： 本发明包括用于预防和/或治疗心血管疾病的化合物。 该化合物是由以下通式（I）表示的化合物的阻转异构体：其中R1表示C1-C3烷基; R2表示2-羟基-C4-C6烷基; R 3表示卤代基，卤代-C 1 -C 3烷基等; R4代表氢原子，卤代基等; R5代表C1-C3烷基; R6表示氢原子，卤代基等]或它们的阻转异构体。

公开(公告)号：US09686122B2

公开(公告)日：2017-06-20

申请号：US13681803

申请日：2012-11-20

申请人： Michael Herzig ,  Matthew Williams ,  Shawn Kerrigan

发明人： Michael Herzig ,  Matthew Williams ,  Shawn Kerrigan

IPC分类号： G06G7/54 ,  H04L12/24 ,  F24J2/38 ,  G06F17/50

CPC分类号： H04L41/026 ,  F24S50/20 ,  F24S2201/00 ,  G06F17/5009

摘要： The present invention relates to methods and systems for identifying PV system and solar irradiance sensor orientation and tilt based on energy production, energy received, simulated energy production, estimated energy received, production skew, and energy received skew. The present invention relates to systems and methods for detecting orientation and tilt of a PV system based on energy production and simulated energy production; for detecting the orientation and tilt of a solar irradiance sensor based on solar irradiance observation and simulated solar irradiance observation; for detecting orientation of a PV system based on energy production and energy production skew; and for detecting orientation of a solar irradiance sensor based on solar irradiance observation and solar irradiance observation skew.

公开(公告)号：US20160322528A9

公开(公告)日：2016-11-03

申请号：US13681803

申请日：2012-11-20

申请人： Michael Herzig ,  Matthew Williams ,  Shawn Kerrigan

发明人： Michael Herzig ,  Matthew Williams ,  Shawn Kerrigan

IPC分类号： H01L31/052 ,  F24J2/38

CPC分类号： H04L41/026 ,  F24S50/20 ,  F24S2201/00 ,  G06F17/5009

摘要： The present invention relates to methods and systems for identifying PV system and solar irradiance sensor orientation and tilt based on energy production, energy received, simulated energy production, estimated energy received, production skew, and energy received skew. The present invention relates to systems and methods for detecting orientation and tilt of a PV system based on energy production and simulated energy production; for detecting the orientation and tilt of a solar irradiance sensor based on solar irradiance observation and simulated solar irradiance observation; for detecting orientation of a PV system based on energy production and energy production skew; and for detecting orientation of a solar irradiance sensor based on solar irradiance observation and solar irradiance observation skew.

公开(公告)号：US20140188410A1

公开(公告)日：2014-07-03

申请号：US13729066

申请日：2012-12-28

申请人： Shawn Kerrigan ,  Nikhil Rajendra ,  Alexander Thornton ,  Matthew Williams

发明人： Shawn Kerrigan ,  Nikhil Rajendra ,  Alexander Thornton ,  Matthew Williams

IPC分类号： G01N27/00 ,  G06F17/50 ,  G01R21/00

CPC分类号： G06F17/50 ,  G01R21/00 ,  G06Q10/04 ,  G06Q50/06 ,  H02J3/383 ,  Y02E10/563

摘要： The present invention provides methods of calibrating photovoltaic model parameters to improve modeling accuracy of photovoltaic power product ion, methods for determining as-built photovoltaic production expectations, methods for determining weather-adjusted photovoltaic performance, methods for determining and quantifying energy losses due to equipment mismatch, methods for determining and quantifying energy losses due to snow, methods for determining and quantifying energy losses due to equipment downtime, methods for determining and quantifying energy losses due to shading, methods for determining and quantifying energy losses due to soiling and equipment degradation.

摘要翻译： 本发明提供校准光伏模型参数以提高光伏发电产品离子的建模精度的方法，用于确定建成的光伏生产期望的方法，用于确定天气调整的光伏性能的方法，用于确定和量化由于设备不匹配引起的能量损失的方法 ，用于确定和量化雪造成的能量损失的方法，确定和量化设备停机时能量损失的方法，确定和定量由于阴影引起的能量损失的方法，确定和量化由于污染和设备退化引起的能量损失的方法。

公开(公告)号：US20130152998A1

公开(公告)日：2013-06-20

申请号：US13681803

申请日：2012-11-20

申请人： Michael Herzig ,  Matthew Williams ,  Shawn Kerrigan

发明人： Michael Herzig ,  Matthew Williams ,  Shawn Kerrigan

IPC分类号： H01L31/052 ,  F24J2/38

CPC分类号： H04L41/026 ,  F24S50/20 ,  F24S2201/00 ,  G06F17/5009

摘要： The present invention relates to methods and systems for identifying PV system and solar irradiance sensor orientation and tilt based on energy production, energy received, simulated energy production, estimated energy received, production skew, and energy received skew. The present invention relates to systems and methods for detecting orientation and tilt of a PV system based on energy production and simulated energy production; for detecting the orientation and tilt of a solar irradiance sensor based on solar irradiance observation and simulated solar irradiance observation; for detecting orientation of a PV system based on energy production and energy production skew; and for detecting orientation of a solar irradiance sensor based on solar irradiance observation and solar irradiance observation skew.

摘要翻译： 本发明涉及用于基于能量产生，能量接收，模拟能量产生，估计的能量接收，生产偏斜和能量接收偏斜来识别光伏系统和太阳辐射传感器取向和倾斜的方法和系统。 本发明涉及基于能量生产和模拟能量产生来检测光伏系统的取向和倾斜的系统和方法; 用于基于太阳辐照观察和模拟的太阳辐照观察来检测太阳辐照传感器的取向和倾斜; 用于基于能量生产和能量生产偏差检测光伏系统的方向; 并且用于基于太阳辐照观察和太阳辐照观察偏斜来检测太阳辐照传感器的取向。