发明申请
US20070212359A1 Cancer Diagnosis And Treatment Of Cancer Using Anti-Robo 1 Antibody
有权
使用抗Robo 1抗体的癌症诊断和治疗癌症
- 专利标题： Cancer Diagnosis And Treatment Of Cancer Using Anti-Robo 1 Antibody
- 专利标题（中）： 使用抗Robo 1抗体的癌症诊断和治疗癌症
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申请号： US11547534申请日： 2005-03-31
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公开(公告)号： US20070212359A1公开(公告)日： 2007-09-13
- 发明人: Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
- 申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
- 申请人地址： JP Tokyo 115-8543
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo 115-8543
- 国际申请： PCT/JP05/06838 WO 20050331
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/574 ; C07K16/30
摘要：
A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
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