发明申请
US20070219149A1 Novel Vaccine Containing Adjuvant Capable Of Inducing Mucosal Immunity
审中-公开
含有能够诱导黏膜免疫的佐剂的新型疫苗
- 专利标题： Novel Vaccine Containing Adjuvant Capable Of Inducing Mucosal Immunity
- 专利标题（中）： 含有能够诱导黏膜免疫的佐剂的新型疫苗
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申请号： US10567766申请日： 2004-08-10
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公开(公告)号： US20070219149A1公开(公告)日： 2007-09-20
- 发明人: Hideki Hasegawa , Takeshi Kurata , Tetsutarou Sata , Masami Moriyama , Shin-ichi Tamura , Takeshi Tanimoto
- 申请人： Hideki Hasegawa , Takeshi Kurata , Tetsutarou Sata , Masami Moriyama , Shin-ichi Tamura , Takeshi Tanimoto
- 申请人地址： JP Suita-shi, Osaka 565-0871 JP Tokyo 162-8640 JP Tokyo 103-8666
- 专利权人： The Research Foundation for Microbial Diseases of Osaka University,Japan as Represented by the Director-General of National Institute of Infectious Diseases,Toray Industries, Inc.
- 当前专利权人： The Research Foundation for Microbial Diseases of Osaka University,Japan as Represented by the Director-General of National Institute of Infectious Diseases,Toray Industries, Inc.
- 当前专利权人地址： JP Suita-shi, Osaka 565-0871 JP Tokyo 162-8640 JP Tokyo 103-8666
- 优先权： JP2003-291879 20030811
- 国际申请： PCT/JP04/11488 WO 20040810
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K39/295 ; A61K39/12 ; A61K39/21 ; A61K39/145 ; A61K39/165 ; A61K39/13 ; A61K39/215 ; A61K39/02
摘要：
The present invention provides an adjuvant that possesses a greater adjuvant potential than that of a conventional adjuvant, and that is capable of producing a protective reaction across different strains. This problem has been solved by the finding that a double-stranded RNA (for example, Poly(I:C)) unexpectedly exhibits the above capability when used in combination with a subunit antigen. Accordingly, the present invention provides a vaccine for mucosal administration containing A) a double-stranded RNA and B) a subunit antigen or inactivated antigen of a pathogen.
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