发明申请
US20070219211A1 Bicyclic Heterocyclic Derivatives and Their Use as Inhibitors of Stearoyl-Coadesaturase (Scd)
失效
双环杂环衍生物及其作为硬脂酰辅酶S（STD）抑制剂的用途
- 专利标题： Bicyclic Heterocyclic Derivatives and Their Use as Inhibitors of Stearoyl-Coadesaturase (Scd)
- 专利标题（中）： 双环杂环衍生物及其作为硬脂酰辅酶S（STD）抑制剂的用途
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申请号： US11575643申请日： 2005-09-20
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公开(公告)号： US20070219211A1公开(公告)日： 2007-09-20
- 发明人: Rajender Kamboj , Jian-Min Fu , Vishnumurthy Kodumuru , Shifeng Liu , Kashinath Sadalapure , Nagasree Chakka , Duanjie Hou , Shaoyi Sun
- 申请人： Rajender Kamboj , Jian-Min Fu , Vishnumurthy Kodumuru , Shifeng Liu , Kashinath Sadalapure , Nagasree Chakka , Duanjie Hou , Shaoyi Sun
- 申请人地址： CA BC Burnaby V5G 4W8
- 专利权人： XENON PHARMACEUTICALS INC.
- 当前专利权人： XENON PHARMACEUTICALS INC.
- 当前专利权人地址： CA BC Burnaby V5G 4W8
- 国际申请： PCT/US05/33738 WO 20050920
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61K31/497 ; C07D403/00 ; C12N9/99
摘要：
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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