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    Pyrrolo[1,2-B]pyridazine compounds and their uses
    3.
    发明申请
    Pyrrolo[1,2-B]pyridazine compounds and their uses 审中-公开

    公开(公告)号：US20060166998A1

    公开(公告)日：2006-07-27

    申请号：US11386385

    申请日：2006-03-22

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: G01N33/53 ,  A61K31/502

    CPC classification number: A61K31/502 ,  G01N33/566 ,  G01N2500/00

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

    Pyrrolo[1,2-B]pyridazine compounds and their uses
    4.
    发明授权
    Pyrrolo[1,2-B]pyridazine compounds and their uses 失效

    公开(公告)号：US07056920B2

    公开(公告)日：2006-06-06

    申请号：US10799407

    申请日：2004-03-12

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: C07D487/04 ,  A61K31/5025 ,  A61P25/22 ,  A61P25/24

    CPC classification number: C07D487/04

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

    Pyrrolo[1,2-b]pyridazine compounds and their uses
    5.
    发明授权
    Pyrrolo[1,2-b]pyridazine compounds and their uses 失效
    吡咯并[1,2-b]哒嗪化合物及其用途

    公开(公告)号：US07041671B2

    公开(公告)日：2006-05-09

    申请号：US10799406

    申请日：2004-03-12

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: C07D487/04 ,  A61K31/5025 ,  A61P25/22 ,  A61P25/24

    CPC classification number: C07D487/04

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

    Abstract translation: 公开了新的CRF受体拮抗剂及其用于治疗多种疾病的用途，包括表现出CRF过度分泌或与CRF或CRF受体如焦虑和抑郁症相关的疾病。 本发明的CRF受体拮抗剂具有式（I）的结构：包括立体异构体或立体异构体的混合物，药学上可接受的前药或其药学上可接受的盐，其中在式（I）中R是H或Me。

    Indoles and indolines having 5-HT activity
    6.
    发明授权
    Indoles and indolines having 5-HT activity 失效
    具有5-HT活性的吲哚和中间体

    公开(公告)号：US07022694B2

    公开(公告)日：2006-04-04

    申请号：US10192918

    申请日：2002-07-11

    Applicant: Jian-Min Fu ,  Jeanette Kay Morris ,  Arthur Glenn Romero

    Inventor： Jian-Min Fu ,  Jeanette Kay Morris ,  Arthur Glenn Romero

    IPC: A61P25/00 ,  A61K31/55 ,  C07D487/00

    CPC classification number: C07D487/04

    Abstract: The present invention provides compounds of Formula (I): wherein R1, R2, R3, R4, R5, R6 and --- have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of Formula (I). The compounds are useful as 5-HT ligands.

    Abstract translation: 本发明提供式（I）的化合物：其中R 1，R 2，R 3，R 4， >，R 5，R 6和 - 具有说明书中定义的任何值，以及包含该化合物的药物组合物。 本发明还提供治疗方法以及可用于制备式（I）化合物的方法和中间体。 该化合物可用作5-HT配体。

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