A semiconductor package structure includes a substrate, a first chip, a second chip, a wire, and an encapsulant. The substrate with a cavity has a first surface and a second surface. The cavity penetrates the first surface and the second surface. The first surface and the second surface have a first solder pad and a second solder pad respectively. The first chip having a first active surface and a first non-active surface is disposed inside the cavity. The first active surface has a first contact pad. The second chip having a second active surface and a second non-active surface is disposed on the second surface. The second non-active surface is adhered to the first non-active surface. The second active surface has a second contact pad. The wire is used for electrically connecting the second contact pad and the second solder pad. The encapsulant disposed on the substrate fills the cavity.